SELECTBIO - Extracellular Vesicles & Cell-Free RNAs 2023 Biographies

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Electrokinetic-based Microchip for Purification and Characterization of Small Extracellular Vesicles

Wednesday, 29 November 2023 at 09:30

Add to Calendar ▼2023-11-29 09:30:002023-11-29 10:30:00Europe/LondonElectrokinetic-based Microchip for Purification and Characterization of Small Extracellular VesiclesExtracellular Vesicles and Cell-Free RNAs 2023 in Laguna Hills, CaliforniaLaguna Hills, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Small extracellular vesicles (sEVs) are lipid-bilayer delimited particles that are naturally secreted by all cells and have emerged as valuable biomarkers for a wide range of diseases. Efficient isolation of sEVs while maintaining yield and purity is crucial to harvest their potential in diagnostic, prognostic, and therapeutic applications. However, because of the complex nature of samples and the heterogeneous physicochemical properties of EVs, their accurate isolation and characterization from body fluids raises significant challenges in clinical settings. We have developed and patented a simple, yet powerful electrokinetic-based microchip capable of rapid and label-free purification of sEVs from body fluids by applying a significantly low electric field. The device also tailored with a sensing module to further characterize sEVs based on their dielectric properties by measuring their impedance. Thus, the microchip has significant potential to serve as a bioanalytical tool for liquid biopsy.

Leyla Esfandiari, Associate Professor of Biomedical Engineering, University of Cincinnati

Leyla Esfandiari received her B.S. in Electrical Engineering from the California State University of Long Beach (CSULB) and her M.Sc. in Biomedical Engineering from the University of California Irvine (UCI). She completed her doctoral degree in Bioengineering from the University of California Los Angeles (UCLA) in 2014. She is currently an Associate Professor of Biomedical Engineering at the University of Cincinnati. She holds secondary appointments in both Electrical Engineering and Environmental and Public Health Sciences at the College of Medicine. Also, she is a member of the Cincinnati Cancer Center and the Center for Stem Cell and Organoid Medicine (CuSTOM) at the Cincinnati Children's Hospital. Her research is mainly focused on developing miniaturized devices, such as sensors and actuators, that can be applied in liquid biopsy and regenerative medicine. Her research has been supported by the National Institute of Health, the National Science Foundation, and the Department of Defense. Dr. Esfandiari has won many awards, including the National Institute of Health (NIH) Maximizing Investigator Research Award (MIRA) in 2023, the National Science Foundation (NSF) CAREER Award in 2021, and the Engineering and Applied Sciences Distinguished Research Award.