Synthetic Substrates for Cellular Control

Tuesday, 25 June 2024 at 10:00

Add to Calendar ▼2024-06-25 10:00:002024-06-25 11:00:00Europe/LondonSynthetic Substrates for Cellular ControlOrganoids and Spheroids Europe 2024 in Rotterdam, The NetherlandsRotterdam, The

The basis of my talk is polymer microarray technology which has been developed in the Bradley group for over 20 years.  In my talk I will introduce polymer microarray technology and describe how this approach has been used in a large number of stem cell based applications – providing cells for a variety of screening applications -  notably:

(i). The use of polymer microarray technology to discover a novel thermo-responsive chemically-defined hydrogel for long term culture of human embryonic stem cells and primary human mesenchymal adipose derived stem cells.

(ii). Polymer discovery that were able to support highly functional hESC-derived hepatocyte like cells (as active as primary human hepatoctyes) (with David Hay).

(iii). The development of polymers that bind cancer stem cells and stop their differentiation) (with Tetsuya Tega) (Stem Cells, 2016).

Mark Bradley, Professor of Therapeutic Innovation, Precision Healthcare University Research Institute, Queen Mary University of London

Mark Bradley

Mark received his doctorate from the University of Oxford in 1989, followed by post-doctoral studies at Harvard and returning to the UK as a Royal Society University Research Fellow (University of Southampton). In 1997 he was made a Professor of Combinatorial Chemistry setting up the UK’s Centre for Combinatorial Chemistry. In 2005 he moved to the University of Edinburgh, where he was Director of a £15M Interdisciplinary Research Collaboration in the area of Optical Molecular Imaging (Proteus 2014-2023) and a Doctorial Training Centre (60PhD) in Optical Imaging with Entrepreneurship. In Aug 2023 he moved to Queen Mary University of London as Professor of Therapeutic Innovation and part of the Precision Healthcare university Research Institute. He held an ERC Advanced Grant on “SmartMaterials” for cellular control. He is a co-founder of Ilika Technologies (2004) (which floated on AIMS in 2010), DestiNA Technologies (2010) and Edinburgh Molecular Imaging (2014) and Biocaptiva (2021).