CNS Organoid Models for Virus Research

Monday, 24 June 2024 at 14:30

Add to Calendar ▼2024-06-24 14:30:002024-06-24 15:30:00Europe/LondonCNS Organoid Models for Virus ResearchOrganoids and Spheroids Europe 2024 in Rotterdam, The NetherlandsRotterdam, The

Virus research historically relies on research using cell lines or animal models. Organoid technology is highly applicable in the virology field, yet unexplored. Organoid systems can mimic the in vivo human physiological environment and provide tools to study human host-virus interactions. The pathogenesis of a variety of human viruses, such as picornaviruses, HIV and human cytomegalovirus (CMV) is increasingly being studied using these novel human organoid models. Human airway epithelium (HAE) cultures and lung organoids allow for host-pathogen interaction studies on viral infections in the respiratory tract (RT), while human gut and brain organoids facilitate human gastro-intestinal tract (GIT) and brain studies. We established human RT (using HAE and lung organoids), GIT (using human gut organoids) and brain (using blood-brain- barrier, whole brain and forebrain organoids) 3D models to study virus infections such as SARS-CoV2, picornavirus, CMV and HIV infections. During the presentation I will share results that are derived from these studies.

Dasja Pajkrt, Professor of Viral Pediatric Infectious Diseases, Amsterdam University Medical Center, Head OrganoVIR Labs

Dasja Pajkrt

Dasja Pajkrt | MD PhD MBA |is Professor of Viral Pediatric Infectious Diseases, University of Amsterdam Faculty of Medicine at the Amsterdam University Medical Center.

She is head of OrganovirLabs (, founder of the Amsterdam Organoid Centers (ORCAU), coordinator of two H2020 programs: Organoid for Virus research (OrganoVIR, and GUT VIrus BRain Axis Technology In OrgaNoid Science (, member of the Dutch network Transition animal-free innovations (TPI). She is a member of the Senate of the University of Amsterdam.

Her expertise is on pediatric viral infections, most specifically on picornavirus, cytomegalovirus and HIV infections. Her research group has multiple scientific publications on clinical disease, viral pathogeneses, host-pathogen interactions and outcomes of pediatric viral infections, published in high profile journals (Clin Inf Dis, Lancet Inf Dis, Neurology, J Exp Med, Blood, Science). She supervised a total of 19 PhD students and >40 medical or graduate students. She published >200 peer reviewed papers.