Organoids with Reversed Biopolarity (ORBs): SARS-CoV-2 Drug Testing and Breast Cancer Progression

Monday, 24 June 2024 at 14:00

Add to Calendar ▼2024-06-24 14:00:002024-06-24 15:00:00Europe/LondonOrganoids with Reversed Biopolarity (ORBs): SARS-CoV-2 Drug Testing and Breast Cancer ProgressionOrganoids and Spheroids Europe 2024 in Rotterdam, The NetherlandsRotterdam, The

This presentation will describe production of sub-millimeter diameter, consistent size and shape, lung, kidney, and mammary organoids that have an inverted, apical-out geometry. These Organoids with Reversed Biopolarity (ORBs) are used in 384 well plates in a single-organoid-per-well format to test drugs and disease physiology. The airway ORBs are infected with high yields with multiple SARS-CoV-2 strains with Omicron variant showing highest viral replication and Delta giving the most inflammatory response. The ORBs also predict anti-viral drug efficacy correctly where conventional 2D cultures give false signals. Early-stage breast cancer progression model studies will also be discussed.

Shuichi Takayama, Professor, Georgia Research Alliance Eminent Scholar, and Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University School of Medicine

Shuichi Takayama

Prof. Shuichi Takayama’s research interests started with bioorganic synthesis at the University of Tokyo and Scripps Research Institute. Subsequently he pursued postdoctoral studies in bioengineered microsystems at Harvard University as a Leukemia and Lymphoma Society Fellow. He spent 17 years at the University of Michigan in the Biomedical Engineering Department and Macromolecular Science and Engineering Program, then moved to the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory School of Medicine in the summer of 2017. He is an associate editor of Integrative Biology and recipient of the Pioneers of Miniaturization Prize.