Relevant 3D In vitro Models For Predictive Screening of Nanodrugs

Monday, 24 June 2024 at 15:00

Add to Calendar ▼2024-06-24 15:00:002024-06-24 16:00:00Europe/LondonRelevant 3D In vitro Models For Predictive Screening of NanodrugsOrganoids and Spheroids Europe 2024 in Rotterdam, The NetherlandsRotterdam, The

Nanoscale systems for drug delivery have received considerable attention over the past decades, as they have the potential to overcome limits associated with conventional drug therapies, providing a solution to medical challenges that urgently require new therapeutic approaches. Nanodrugs can improve the therapeutic index of the loaded drug by providing protection against degradation, enabling controlled release and distribution, and increasing bioavailability. Advanced functionalization strategies have been used to confer them long-circulating properties  and facilitate targeting to specific cells. These efforts have led to the introduction into clinical practice of a few nanoscale systems for tumor therapy. However, their small number, compared to the variety of promising systems proposed, reveals a considerable gap between favorable preclinical results and real clinical performance. Biological barriers, inherent to tumors and their microenvironments, pose formidable challenges. To bridge this gap, our focus turns to three-dimensional (3D) culture methodologies. Unlike conventional 2D cultures, 3D models better replicate the heterogeneity, pathophysiology, and structural architecture of real tumors. Our ongoing efforts involve constructing heterotypic multicellular 3D tumor spheroids, serving as robust screening tools. This approach aims to enhance our understanding of nanodrugs penetration and accumulation within the tumor mass. By identifying key parameters, we strive to maximize therapeutic benefits. In an upcoming talk, I will share the most significant results from our research in this evolving field.

Simona Mura, Full Professor, Université Paris-Saclay

Simona Mura

Simona Mura is Full Professor of Pharmaceutical Technology at the Faculty of Pharmacy of the University of Paris-Saclay. After completing her Pharmacist degree at the University of Cagliari in Italy, she pursued a PhD in Chemistry and Technology of Drugs, graduating in 2009 under the guidance of Professor A.M. Fadda. Her doctoral research focused on the design and in vitro evaluation of innovative vesicular systems for the topical delivery of drugs. Following this, she continued her academic journey by joining the research group led by Professor E. Fattal at the Institut Galien, UMR CNRS 8612, University Paris-Sud in France. In this post-doctoral role, she investigated the lung toxicity of biodegradable nanoparticles specifically designed for pulmonary drug administration. In 2011, she was promoted to the position of Associate Professor at the same university. During the period from 2011 to 2016, she was affiliated with the CNRS through the Chaires d'excellence program, conducting research in the team led by Professor P. Couvreur. In 2015, she has been appointed Visiting professor at the Osaka University (Group of M. Akashi) and in 2017 she integrated the prestigious Institut Universitaire de France (IUF) as Junior member. She has been awarded her HDR (Accreditation to conduct research) in 2018 and in September 2022 she has been appointed full Professor. She conducts research at the interface of chemistry, physical chemistry, and biology, with a primary emphasis on developing biomimetic drug delivery systems. Her work involves investigating the behavior of nanomedicines within the complex biological environment of the human body, from the administration site to the targeted action site. This research is achieved through the integration of biomimetic 3D culture techniques, microfluidic technology, and advanced characterization methods.