Advances in Upscaling Microreactor Systems for Production of Drug Chemicals

Thursday, 14 November 2019 at 12:00

Add to Calendar ▼2019-11-14 12:00:002019-11-14 13:00:00Europe/LondonAdvances in Upscaling Microreactor Systems for Production of Drug ChemicalsFlow Chemistry Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com

Continuous-flow technology is emerging for efficient, sustainable and safe synthesis of drug and the precursors. Scale-up production approach is generally achieved by numbering-up microreactors in parallel as well as increasing channel size-up. At here, we present various economic numbering-up microreactor systems with robustness for scale-up production of several drug compounds. The stacked stainless steel metal microreactors and portable polymer pad are developed to demonstrate a drug via azide-alkyne reaction, fast synthesis of organophosphates in a cost-effective and single-step manner. Moreover, an upscaling photocatalysis in flow is also performed in an multi-capillary assembly system for synthesis of indazoles with improved productivity.

Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH)

Dong Pyo Kim

Professor Dong-Pyo Kim has extensive general experience and more than 25 year track record in synthetic and physical organic chemistry, process intensification using microreactors and flow chemistry/microreaction technology, communicated in ~300 scientific publications (h-index 52, citation 8,133). For the past decade the focus of his research has been directed towards flow chemistry using microreactor, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and sustainable manufacturing, employing a number of different enabling and process intensification technology.