Single Cell Sequencing from Technology to Biology and Medicine
Xinghua Victor Pan,
Research Scientist,
Yale University
Single-cell sequencing methods emerged for only a few years have been developed that permit the comprehensive and precise analysis of the genome, transcriptome and epigenome of single cells. The use of these methods to variants of biological systems such as cancers, stem cells, immune cells, neurons, development and differentiation has led to a series of unanticipated discoveries, including the high heterogeneity and new subpopulations with molecular characterization, and the biomarkers of variants of diseases especially cancers. These methods and the knowledge gained from their utilization improve the early and non invasive genetic detection of diseases and promote precise medicine. We will outline the current progresses and applications, particularly those contributed from our laboratory. (ref: Cancer Res; 76(6):1305).
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