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SELECTBIO Conferences 2D-to-3D Culture and Organoids 2020

2D-to-3D Culture and Organoids 2020 Agenda


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Wednesday, 25 March 2020

00:00

Terry RissConference Chair

Title to be Confirmed.
Terry Riss, Global Strategic Marketing Manager Cell Health, Promega Corporation, United States of America

00:00

Gary GintantKeynote Presentation

Title to be Confirmed.
Gary Gintant, Senior Research Fellow, Abbvie, United States of America

00:00

Matthias von HerrathKeynote Presentation

Modeling Immune Mediated Beta Cell Destruction in Human Type 1 Diabetes with Organoids
Matthias von Herrath, Vice President and Senior Medical Officer, Novo Nordisk, Professor, La Jolla Institute, United States of America

In the past 15 years we have been studying the pathology of human type 1 diabetes with access to donor pancreata through the human pancreatic organ donor consortium (nPOD). These studies have led to several findings, for example that certain cytokines are generated by beta cells themselves, sometimes under stress, and also that there are probably key factors that render beta cells susceptible to immune attacks. Mechanistically, the importance and meaning of these observations needs to be addressed in a suitable and easily manipulable in vitro system consisting of human islets and immune cells. We have built such a system in collaboration with the company InSphero and will discuss emerging findings.

00:00

Donna MendrickKeynote Presentation

Alternative Models Use: Regulatory Context
Donna Mendrick, Associate Director of Regulatory Activities, US Food and Drug Administration (FDA), United States of America

In 2017 FDA published the Predictive Toxicology Roadmap (https://www.fda.gov/science-research/about-science-research-fda/fdas-predictive-toxicology-roadmap)-a framework for integrating predictive toxicology methods into safety and risk assessments.  FDA welcomes data from alternative methods and is working internally and externally to learn more about technologies such as MPS.  This presentation will provide an overview of MPS work being done within FDA and the actions being taken to help move alternative assays into a regulatory context.

00:00

Tissue Organoids For Disease Modeling
Shay Soker, Professor of Regenerative Medicine, Wake Forest Institute for Regenerative Medicine, United States of America

Traditional in vitro two dimensional (2D) cell cultures fail to recapitulate the microenvironment of in vivo tissues. They have three major differences from native tissue microenvironments: substrate topography, substrate stiffness, and most importantly, a 2D rather than three dimensional (3D) architecture. In contrast, 3D human tissue organoids replicate native tissue structure and function and thus are superior to traditional 2D cultures and animal models. These organoids can be studied in vitro for several weeks to allow intensive investigations. Besides their advantages in drug toxicity testing and for development of new drugs, the human tissue organoid platform serves as a model system to explore human tissue development and disease. Our recent research was focused on the use of human tissue organoids to study liver development and congenital diseases as well as other common diseases such as tissue fibrosis and cancer. Altogether our human tissue organoids system can be used for modeling of a wide verity of diseases and develop new personalized/precision medicine applications.


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Add to Calendar ▼2020-03-25 00:00:002020-03-26 00:00:00Europe/London2D-to-3D Culture and Organoids 20202D-to-3D Culture and Organoids 2020 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com