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SELECTBIO Conferences 3D-Printing in the Life Sciences

3D-Printing in the Life Sciences Agenda



Co-Located Conference Agendas

The Space Summit 2019 | 

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Monday, 14 October 2019

00:00

Force Sensing Microtissue Arrays For Disease Modeling and Drug Discovery in Fibrosis and Abnormal Clotting
Ruogang Zhao, Assistant Professor, SUNY Buffalo, United States of America

This talk will describe our recent development of microtissue array systems with tissue morphogenesis and force sensing capabilities. These mechanically-active 3D microtissue models have been shown as powerful tools for disease modeling and drug discovery. Using microfabricated arrays of flexible micropillars, we generated lung alveolar-like, contractile microtissues for the screening of anti-fibrosis drugs. We provided proof of principle for using this fibrotic tissue array for multi-parameter, phenotypic analysis of the therapeutic efficacy of two anti-fibrosis drugs recently approved by the FDA. We also developed force sensor-coupled collagen microtissues for the modeling of normal and abnormal blood clotting under shear flow. Studies with antagonists and diseased patient plasma demonstrate the ability of the system to assay clot biomechanics associated with both common antiplatelet treatments and bleeding disorders.

00:00

Axel GuentherKeynote Presentation

Handheld Skin Printer: In-Situ Formation of Biomaterials and Skin Tissues
Axel Guenther, Associate Professor and Co-Lead, Collaborative Centre for Research and Applications in Fluidic Technologies (CRAFT), University of Toronto, Canada

I discuss the in-situ delivery of biomaterials and cells for skin tissue repair. We developed a handheld skin bioprinter, specifically for intraoperative use. I will discuss unique features of the handheld bioprinter instrument, physical and in vitro characterization of in-situ deposited biomaterials and tissues, as well as in vivo results that were obtained in porcine wound in collaboration with Dr. Marc Jeschke’s team at Sunnybrook Health Sciences Center in Toronto.

00:00

Title to be Confirmed.
Thomas Angelini, Associate Professor, Department of Mechanical and Aerospace Engineering, University of Florida, United States of America

00:00

Shaochen ChenKeynote Presentation

Title to be Confirmed.
Shaochen Chen, Professor and Vice Chair of NanoEngineering, Co-Director of Biomaterials and Tissue Engineering Center, University of California-San Diego, United States of America

00:00

Albert FolchKeynote Presentation

High-Resolution 3D-Printing of Microfluidics
Albert Folch, Professor of Bioengineering, University of Washington, United States of America

The vast majority of microfluidic systems are built by replica-molding in elastomers (such as PDMS) or in thermoplastics (such as PMMA or polystyrene). However, biologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. Several groups, including ours, have been developing microfluidic devices through stereolithography (SL), a form of 3D printing, in order to make microfluidic technology readily available via the web to biomedical scientists. However, most available SL resins do not have all the favorable physicochemical properties of the above-named plastics (e.g., biocompatibility, transparency, elasticity, and gas permeability), so the performance of SL-printed devices is still inferior to that of equivalent PDMS devices. Inspired by the success of hydrogel PEG-DA biocompatibility, we have developed microfluidic devices by SL in advanced resins that share all the advantageous attributes of PDMS and thermoplastics so that we can 3D-print designs with comparable performance and biocompatibility to those that are presently molded.

00:00

Title to be Confirmed.
Luiz Bertassoni, Assistant Professor, Oregon Health & Sciences University, United States of America

00:00

AlleviHow 3D Bioprinting Begins To Take Shape In Industry
Ricky Solorzano, CEO, Allevi

3D bioprinting has been a very promising technology to allow more and more research to be published and new discoveries made. However, how does bioprinting begin to penetrate the industrial sector? What specific areas should the field focus on? How can we measure impact?

00:00

Y. Shrike ZhangConference Chair

Putting 3D Bioprinting to the Use of Tissue Model Fabrication
Y. Shrike Zhang, Assistant Professor of Medicine and Associate Bioenginering, Harvard Medical School, Associate Bioengineer, Division of Engineering in Medicine, Brigham and Women’s Hospital, United States of America

The talk will discuss our recent efforts on developing a series of bioprinting strategies including sacrificial bioprinting, microfluidic bioprinting, and multi-material bioprinting, along with various cytocompatible bioink formulations, for the fabrication of biomimetic 3D tissue models. These platform technologies, when combined with microfluidic bioreactors and bioanalysis, will likely provide new opportunities in constructing functional microtissues with a potential of achieving precision therapy by overcoming certain limitations associated with conventional models based on planar cell cultures and animals.

00:00

Engineering Human Tissues Using 3D Bioprinting Technology
Jinah Jang, Assistant Professor, Pohang University of Science And Technology (POSTECH), Korea South

Recent development in bioengineering enables us to create human tissues by integrating various native microenvironments, including tissue specific cells, biochemical and biophysical cues. A significant transition of 3D bioprinting technology into the biomedical field helps to improve the function of engineered tissues by recapitulating physiologically relevant geometry, complexity, and vascular network. Bioinks, used as printable biomaterials, facilitate dispensing of cells through a dispenser as well as supports cell viability and function by providing engineered extracellular matrix. Successful construction of functional human tissues requires accurate environments that are able to mimic biochemical and biophysical properties of target tissue. Formulation of printable materials with stem cells are critical process to guide cellular behavior; however, this is rarely considered in the context of bioprinting in which the tissue should be formed. This talk will cover my research interests in building 3D human tissues and organs to understand, diagnose and treat various intractable diseases, particularly for cardiovascular disease. A development of tissue-derived decellularized extracellular matrix bioink platform will be mainly discussed as a straightforward strategy to provide biological and biophysical phenomena into engineered tissues. I will also discuss about a development of 3D vascularized cardiac stem cell patch that is generated by integrating the concept of tissue engineering and the developed platform technologies. Combined with recent advances in human pluripotent stem cell technologies, printed human tissues could serve as an enabling platform for studying complex physiology in tissue and organ contexts of individuals.

00:00

Ali KhademhosseiniKeynote Presentation

Title to be Confirmed.
Ali Khademhosseini, Professor, Department of Bioengineering, Department of Radiology, Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, United States of America

00:00

Hayden TaylorKeynote Presentation

Computed Axial Lithography For Volumetric Printing of Soft Structures
Hayden Taylor, Assistant Professor, Mechanical Engineering, University of California-Berkeley, United States of America

Volumetric additive manufacturing is defined as producing the entire volume of a component or structure simultaneously — rather than by layering — and has been envisioned as a possible way to increase the speed of additive manufacturing. Until recently, however, no practicable technique existed for creating arbitrary 3D geometries volumetrically. Recently, we have demonstrated Computed Axial Lithography (CAL) to meet this need. CAL essentially reverses the principles of computed tomography (widely used in imaging, but not previously in fabrication) to synthesize a three-dimensionally controlled illumination dose within a volume of photocurable resin. The photosensitive volume rotates steadily while a video projector illuminates the material from a direction perpendicular to the axis of rotation. The illumination pattern typically changes >1000 times per revolution, so that light from many different projection angles contributes to the cumulative dose. Where the dose exceeds a threshold, the resin solidifies and the part is formed. In this talk I will discuss the CAL process in the context of its possible bioprinting applications. The CAL printing technique has several potential advantages. Because there is no relative motion between the component being printed and the resin during printing, the printing speed is not limited by resin flow effects, as it can be in layer-by-layer photopolymerization-based printing. The absence of relative motion also allows highly viscous resins or soft, highly compliant materials such as hydrogels to be printed. Because layers are not used in CAL, the surfaces of printed components are very smooth (c. 1–4 µm roughness in preliminary experiments), which may open up new applications. Additionally, it is possible to print objects around pre-existing solid objects that could have been made using a different material or process. This ‘overprinting’ capability suggests applications in mass-customization for end users and also potentially in fabricating biological structures with highly heterogeneous mechanical properties.

00:00

CELLINKBioprinting of Human Soft Tissues
Patrick Thayer, Chief Application Officer, CELLINK

Discussion of how bioprinting techniques can be utilized to enable the fabrication of human soft tissues.

00:00

Hybrid Laser Platform for Printing 3D Multi-Scale Multi-Material Hydrogel Structures
Pranav Soman, Assistant Professor, Biomedical and Chemical Engineering , Syracuse University, United States of America

Over the course of billions of years, nature has created and refined numerous elegant biosynthetic processes to make sophisticated functional structures. In contrast, current manufacturing techniques are still limited in their ability to fabricate 3D multiscale multi-material structures. Few research groups have utilized the ability of ultrafast lasers to shape hydrogel materials into complex 3D structures. However, current laser based methods are limited by scalability, types of materials, and incompatible laser and materials processing requirements, thereby preventing its widespread use in the field. In this work, we report the design and development of a Hybrid Laser Printing (HLP) technology, that combines the key advantages of additive stereolithography (quick on-demand continuous fabrication) and multiphoton polymerization/ablation processes (high-resolution and superior design flexibility). Using a series of proof-of-principle experiments, we show that HLP is capable of printing 3D multiscale multi-material structures using model biocompatible hydrogel materials that are highly difficult and/or extremely time consuming to fabricate using current technologies.


Agenda is not currently available
Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/London3D-Printing in the Life Sciences3D-Printing in the Life Sciences in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com