ADME & Predictive Toxicology Europe Agenda

Registration

Safety Pharmacogenomics
Urs Meyer, Emeritus Professor, Biozentrum/University of Basel, Switzerland

This lecture will give an update on the presently required mandatory pre-prescription tests for safety biomarkers and their clinical application and also discuss the recommended non-mandatory tests or still disputed applications of safety pharmacogenomics.

Coffee Break and Networking in the Exhibition Hall

The Role of Defence and Adaptation in Drug-Mediated Liver Toxicity
Christopher Goldring, Senior Lecturer, University of Liverpool, United Kingdom

Chemical stress is a potentially deleterious state induced by exposure of cells to non-physiological levels of chemically reactive species (CRS) and it can play a role in off-target adverse drug reactions (ADRs). Whilst we are beginning to understand some of the key events that influence how the liver adapts to exposure to chemicals, we are still some distance from understanding how this actually pertains to Man. This talk will review the field and highlight key recent developments and the most significant challenges to our understanding as to whether defence and adaptation influences individual susceptibility.

Rationalising Reactive Toxicity: From Chemistry to Adverse Effects
Mark Cronin, Professor, Liverpool John Moores University, United Kingdom

Many drug toxicities are brought about through reactive metabolites. The chemistry associated with reactivity will be described and will allow for the prediction of adverse effects and systemic toxicity.

Technology Spotlight:
ADME Studies in Knockout Rats Lacking Key Drug Transporters
Heike Lehrmann, Tactical Marketing Manager, Sigma Aldrich

Lunch

Poster Viewing Session

When is a Genotoxin not a Genotoxin?
Richard Walmsley, Professor, University of Manchester, United Kingdom

The in vitro genotoxicity tests were conceived to predict carcinogenicity in novel chemicals. However a reproducibly positive in vitro genotoxicity test result does not necessarily imply a human cancer hazard. This talk explores how chemicals can be saved.

A Pharma-Wide Approach to Predicting the Genotoxic Properties of Aromatic Amines
Michael Kranz, Computational Chemist, GlaxoSmithKline, United Kingdom

In this talk, the reliability of the Ames test for AA’s, the outcome from a pharmacy-wide data-sharing consortium for building block-sized AA’s and a new predictive model will be presented.

Coffee Break and Networking in the Exhibition Hall

Biotransformation: Still a Bottleneck for In Vitro Kinetic and Dynamic Approaches?
Sandra Coecke, Laboratory Leader, Joint Research Center, Germany

Essential input parameters for physiologically-based toxicokinetic and toxicodynamic modelling rely on the availability of reliable and relevant human metabolic competent sources, modelling the process of xenobiotic biotransformation.

In Silico Predictive Toxicology: Where are we at and Where are we Going?
John Dearden, Professor, Liverpool John Moores University, United Kingdom

In silico toxicology has made great strides in recent years, and both the range of endpoints and the accuracy of predictions have improved. There is, however, still much room for improvement. Mechanistic and toxicokinetic approaches are now being used that are allowing better predictions to be made.

Drinks Reception

The Xenometabolome – Implications and Opportunities for Health and Disease
Richard Barton, Research Fellow, Imperial College London, United Kingdom

The relationship between man and ecologies formed of both commensal and pathogenic bacteria presents complex metabolic features which range beyond simple host-organism metabolic properties. This presents both problems and opportunities for advancing our approach to disease pathogenesis and treatment.

Coffee Break and Networking in the Exhibition Hall

Lunch

Poster Viewing Session

In Vitro and In Vivo Models to Develop New Therapies for Renal Diseases
Frederick Tam, Reader/Associate Professor, Imperial College London, United Kingdom

Cytokines are important in the pathogenesis of renal diseases, such as glomerulonephritis and diabetic nephropathy. In vitro study of renal cells and glomeruli and in vivo rodent models of renal diseases are invaluable in development of as new therapies.

Coffee Break and Networking in the Exhibition Hall

Characterization of Uptake Transporters in Cell-Based Penetration Models of Blood-Brain Barrier
Monika Vastag, Laboratory Head, Gedeon Richter Plc, Hungary

This talk will compare the expression and activity of uptake transporters involved in the physiology of BBB and transportation of drugs to the brain. In-house generated data will be presented in models of blood-brain barrier like the triple co-culture model using brain derived cells, the MDCK-MDR1 and the recently introduced VB-Caco-2 cultures.

Predicting Oral Drug Likeness
Amiram Goldblum, Head, Hebrew University of Jerusalem, Israel

We present a new method to score molecules for their oral drug-likeness which is based on distinguishing their properties from others, and prioritizing them by an Index called OB-DLI Orally Bioavailable Drug Like Index).

Close of Conference