Formulation and Solubility Agenda

Registration

Systems Biology and Oral Drug Absorption
Afzal Mohammed, Senior Lecturer, Aston University, United Kingdom

The overarching aim of my presentation will be to investigate genomic changes of transporter genes when studied as a singular system during the process of drug permeation. My presentation will comprise of two sections: the first section will focus on formulation development of solid dispersions to enhance drug solubility and the second section will be dedicated to understanding transcriptomic changes of drug transporters during permeability studies. The conclusion of my presentation will describe the role of pharmaceutical formulation and excipients in drug transport and how studies based on systems biology can help formulation scientists towards improved drug delivery and targeting.

What is Good Solubility?
Rene Holm, Head, H Lundbeck A S, United States of America

The talk will cover simple drugability methods to evaluate solubility and in vitro and in vivo studies to clarify pharmaceutical developability.

Coffee Break and Networking in the Exhibition Hall

Experimental Techniques for Studying Solubility Enhancement
John Comer, Chief Scientific Officer, Sirius Analytical Instruments, United Kingdom

High Drug Capacity and Multi Drug Micelles From Doubly Amphiphilic Poly(2-oxazoline)s
Robert Luxenhofer, Professor, Technische Universitat Dresden, Germany

Doubly amphiphilic poly(2-oxazoline)s are biocompatible and accessible by living polymerization. The doubly amphiphilic nature allows for solubilization of unprecedented amounts of extremely hydrophobic drugs, such as paclitaxel or 17-AAG in highly stable micelles of small size (< 100 nm).

Lunch and Networking in the Exhibition Hall

Poster Session

Nanoparticles of Poorly Soluble Drugs
Lennart Lindfors, Principle Scientist/Adjunct Professor, AstraZeneca/University of Gothenberg, Sweden

In the presentation the preparation of crystalline as well as amorphous nanosuspensions will be described as well as the characterization of such systems. The latter will focus on stabilizer adsorption, Ostwald ripening and the dissolution rate of drug nanoparticles.

Role of Delivery Technogies in Improving Therapeutic Efficacy of Poorly Soluble and Permeable Compounds
M Kumar, Professor, University of Strathclyde, United Kingdom

Coffee Break and Networking in the Exhibition Hall

Design and Fate of an Injected Sustained-Release Formulation
Randall Mrsny, Professor, University of Bath, United Kingdom

Optimizing the therapeutic outcomes for some biotherapeutics requires the use of delivery systems that matches the physical and chemical properties of the drug with the biological requirement of their actions. One such example is provided along with a generalized stately for this process.

CANCELLED - Sequence-Specific Peroxide Formation and Unusual Cleavage Reactions of Biomolecules under Conditions of Accelerated Stability Studies
Christian Schoneich, Professor, University of Kansas, United States of America

Drinks Reception

Drug Delivery Systems Designed in-silico
Jamshed Anwar, Professor, University of Bradford, United Kingdom

I shall review the reasons why computer modelling is still relatively un-exploited by the pharmaceutical sector, give details of the methods with selected applications including prediction of solid state properties such as solubility, and then give a perspective for the future.

CANCELLED - Advancing Formulation Development in Drug Discovery : A Novel High Throughput Screening Approach
Alan Wilson, Vice President, Lexicon Pharmaceuticals, United States of America

In my presentation, I will cover the following topics 1) Discovery formulations: changing the formulation paradigm 2) Impact of excipients and solubility on oral bioavailability 3) A novel, high throughput formulation screening method adapted to the discovery environment 4) The Impact of early formulation screening on Pharmacokinetic & Pharmacology.

Coffee Break and Networking in the Exhibition Hall

Design of Crystallisation for Targeted Drug Dissolution
Zoltan Nagy, Professor, University of Loughborough, United Kingdom

Novel model-based and model-free crystallisation control approaches will be presented, which are based on real time feedback control systems using process analytical technologies that allow the design of crystal size distribution and shape to achieve a desired in vivo or in vitro dissolution of the drug.

Prediction of in vivo Performance: Tools for Accurate IVIVCs
Nikoletta Fotaki, Lecturer, University of Bath, United Kingdom

The pros and cons of several methods used for the prediction of the in vivo performance from early to late stage of drug development will be discussed. The factors that need to be taken into account for a predictive in vitro testing will be described and practices for the development of in vitro-in vivo relations and in vitro-in vivo correlations in several stages of development will be presented. Case studies and examples will be included in the presentation.

Lunch and Networking in the Exhibition Hall

Poster Session

Third Generation Solid Dispersions as a Strategy to Improve Drug Bioavailability
Teofilo Vasconcelos, Researcher/Formulation Scientist, Laboratorios BIAL, Portugal

The third generation of solids dispersions are one of the most promising technologies that may allow the administration of poor water soluble drugs in a reliable and consistent manner, improving their bioavailability.

Methods to Improve Bioavailability in Oral Dispersible Tablets (ODTs)
Rosie McLaughlin, Technical Director, Catalent Pharma Solutions, United States of America

The majority of orally disintegrating tablets (ODTs) despite their fast disintegration times exhibit bioequivalence to conventional oral tablets. This presentation will show how lyophilized ODTs can offer flexibility in formulation design to improve oral bioavailability.

Coffee Break and Networking in the Exhibition Hall

Application of Imaging Techniques to Oral Dosage Forms. Examples of in-situ Imaging
Paolo Avalle, Senior Research Chemist, Merck, Switzerland

Modern formulation efforts not only are devoted to improve the solubility of the drugs with effective formulation strategies but also to tune the drug release profile to meet the desired pharmacokinetic criteria. This talk will be based on the characterization of drug-polymers system either as a way to improve solubility but also to change the mechanism of drug release. The focus will be on imaging characterization techniques.

Do not Forget the Patient - Product Design Strategies for Patient Centric Drug Delivery
Sven Stegemann, Director, Capsugel, Belgium

Drug therapy includes a patient suffering from a disease and a therapeutic drug targeted against this disease. Patient centric drug delivery is converting the therapeutic moiety into a drug product that is appropriate for the patients needs, especially within the pediatric and geriatric patient population.

Close of Conference