Lab-on-a-Chip European Congress Agenda

Registration

Microfluidics – an Essential Tool for Product Development in the Life Sciences
Holger Becker, Chief Scientific Officer, Microfluidic ChipShop GmbH, Germany

In the product development process of current systems in the Life Sciences and Diagnostics, microfluidics technology plays an instrumental role. In this presentation, with the help of examples of highly integrated microfluidic devices, we will highlight challenges and opportunities of using advanced miniaturization technologies in the product development process.

Microfluidics Systems for Enhancing Life Science Applications such as in situ Hybridization and in vitro Stem Cell Cultures
Martin Dufva, Associate Professor, Technical University of Denmark, Denmark

A library of miniaturized standardized components was realized for creating various compact, portable, robust and easy to use microfluidics systems. The component library is designated MainSTREAM and is used for dual in situ hybridization assays, microarray based genotyping, stem cell programming.

Coffee Break and Networking in Main Exhibition Hall

Lunch and Networking in Main Exhibition Hall

Free Workshop
Advancement of Separation, Purification and Crystallography from Agilent Technologies
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Poster Presentations

Free Workshop
High Content Screening for Compounds and Genes Affecting Bacterial and Viral Infections
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Integration of Femtosecond Laser Written Optical Sensors in a Lab-on-a-Chip
Giulio Cerullo, Professor, Institute of Photonics and Nanotechnologies, Italy

We demonstrate the integration of femtosecond laser written optical waveguides and photonic devices in commercial fused silica lab-on-a-chips. We present applications to separation and detection of fluorescently labelled DNA fragments, and refractive index sensing with a 3D Mach-Zehnder interferometer.

Coffee Break and Networking in Main Exhibition Hall

Molecular Isolation on the Micro and Nanoscale
Joshua Edel, Professor, Imperial College London, United Kingdom

We report a novel method to fabricate nanopores with apparent diameters below 20 nm for biomolecular sensing.

Integrated "BioCameras" in Chips
Liv Furuberg, Chief Scientist, SINTEF, Norway

We present a new optical biosensor principle for on-chip protein and DNA analyses for diagnostics. The biosensor generates a detectable signal from a few target molecules, has a high dynamic detection range and provides rapid results.

Lab-on-a-Chip Optical Biosensor for Enzyme Activity Sensing
Karl-Heinz Feller, Head, Jena University of Applied Sciences, Germany

The commonly used assay for measuring glucose oxidase (GOx) and laccase (Lac) activity, based on spectrophotometric test using 2,2'-azinobis-(-3 ethylbenzothiazoline-6-sulfononic acid) (ABTS) have been adapted to measure these enzyme activities in micro-structured devices.

Drinks Reception

Free Workshop
PCR without DNA purification – Thermo Scientific Direct PCR
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Multifunctional Nanoparticles for an Integrated Microfluidic Diagnosis System
Sofia Dembski, Researcher, Fraunhofer Institute for Silicate Research, Germany

The great potential of nanoparticles in early diagnosis was recently demonstrated by a joint research project aiming to create a portable microfluidic diagnostic device capable of simultaneously detecting relevant biomarkers such as e.g. tumor-specific or cardiological markers with detection sensitivity even below 10-11 mol/l.

A Multiplexed Localized Surface Plasmon Based Biosensor Based on Gold Nanorings for Point of Care Applications
Liesbet Lagae, Group Leader, IMEC, Belgium

A compact lab on chip system, cheap and easily parallelizable, was developed based on the localized surface plasmon resonance (LSPR) properties of gold nanoring covered substrates integrated with a multichannel microfluidic disposable and a compact CCD read out. The device was applied to simultaneously monitor the biomolecular interactions with label free and in real-time for both proteins and DNA. The investigation of the kinetic biomolecular interactions give a good indication how assay times could be further reduced of particular importance for point-of-care diagnostic applications. Furthermore, we will show the potential of these gold nanostructures for advanced LSPR sensing and Surface Enhanced Raman Scattering (SERS) spectroscopy.

Coffee and Networking in Main Exhibition Hall

Rapid Clinical Diagnostics in a Continuous Flow Lab-on-a-Chip
Nicole Pamme, Professor in Analytical Chemistry, Stockholm University, Sweden

We present a fast, highly versatile microfluidic platform which utilises mobile magnetic particles for performing surface-based assays in continuous flow within a fraction of the time required for conventional methods.

Recent Advances in Separating, Counting and Identification of Bioparticles in Centrifugal Lab-on-a-Chip Systems
Jens Ducrée, Doctor, Dublin City University, Ireland

This presentation highlights recent advances of high-efficiency particle capture, retention, counting, identification and aliquoting by making specific use of the centrifugal volume force, scale-matched geometrical features and integrated actuation. These lab-on-a-disc technologies leverage new applications such as the definition and counting of total particle numbers as well as multiplexed screening in bead and cell based assays implemented on low-complexity instrumentation.

Lunch and Networking in Main Exhibition Hall

Free Workshop
Glosensor Technology: Intracellular Biosensors to Detect Signal Transduction in Living Cells
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Poster Presentations

Free Workshop
Automatic High Content Screening for Life Sciences
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Applications of Microchip Acoustophoresis
Thomas Laurell, Professor, Lund University, Sweden

Acoustophoresis allows non-perturbing manipulation and separation of cells in microfluidic systems. This opens the route to rapid processing of crude biological samples for medical diagnostics as well as other biofluids. The recent advancements of acoustophoresis and applications within life science will be overviewed.

Coffee and Networking in Main Exhibition Hall

Two-Dimensional Protein Separation in Microfluidic Devices
Z Fan, Professor, University of Florida, United States of America

Two-dimensional protein electrophoresis has been implemented in plastic microfluidic devices. An array of microvalves was integrated for introducing different separation media. The total separation time was much shorter than the conventional approach.

Polymeric Micro-Fabricated TiO2-ZrO2 Affinity Chromatography Microchip for Phosphopeptide Enrichment and Separation
Katerina Tsougeni, NCSR Demokritos, NCSR Demokritos, Greece

We demonstrated a completely microfabricated affinity microcolumn on a polymeric chip design for the effective enrichment and separation of phosphopeptides using off-chip MALDI MS identification. The microcolumn exhibited large chromatographic capacity and can be used several times with reproducible results.

Close of Conference