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SELECTBIO Conferences Point-of-Care Diagnostics, Global Health & Biosensors 2019

Point-of-Care Diagnostics, Global Health & Biosensors 2019 Agenda


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Monday, 7 October 2019

00:00

Development of an HIV-1 Viral Load POC Test
Jonathan D Posner, Professor of Mechanical Engineering & Chemical Engineering, University of Washington, United States of America

The HIV/AIDS epidemic continues to be a major global health challenge, and accurate, affordable HIV-1 viral load testing is increasingly needed at the point-of-care (POC). Nucleic acid amplification tests (NAATs) provide high diagnostic accuracy of infectious diseases, yet most systems are restricted to central laboratories due to assay and instrumentation complexity. Here we describe a paper membrane based NAAT with integrated sample preparation and amplification using isotachophoresis and recombinase polymerase amplification.  This approach has the potential to reduce the cost and complexity of point-of-care (POC) NAATs. We demonstrate the detection of HIV-1 nucleic acids in whole blood. Preliminary data demonstrate linearity at low copy number which may provide valuable quantitative data on the HIV viral load of a patient.

00:00

Harnessing Evaporation-Driven Capillary Flow For Point-of-Care Diagnostics
Andres Martinez, Associate Professor, California Polytechnic State University, United States of America

Paper-based microfluidic devices, also known as microPADs, offer a promising platform for the development of point-of-care assays for use in remote, resource-limited settings. Like conventional microfluidic devices, microPADs can be used to manipulate and analyze small volumes of fluids. Paper-based devices are also inexpensive to fabricate, portable, simple to operate, and can complete an assay without relying on electrical power or supporting equipment. MicroPADs typically wick fluids by capillary action, which provides a convenient mode of moving fluids through the device. This presentation will describe evaporation-driven capillary flow as a complementary approach for moving fluids through paper-based devices and the application of this approach toward automating multi-step assays that require a timed sequence of events.

00:00

Title to be Confirmed.
Jane Brock, Chief of Breast Pathology, Brigham and Women’s Hospital, Harvard Medical School, United States of America

00:00

Holger SchmidtKeynote Presentation

Title to be Confirmed.
Holger Schmidt, Narinder Kapany Professor of Electrical Engineering, University of California-Santa Cruz, United States of America

00:00

Microfluidic ChipShop GmbHCome On Baby Light My Fire – Combining Photonics and Microfluidics For Point-of-Care Applications
Holger Becker, Chief Scientific Officer, Microfluidic ChipShop GmbH

Any diagnostic systems, involving microfluidics or other technologies, contain a detection module as a central system component. For many years, fluorescence has been the gold standard, both due to its sensitivity as well as versatility. In recent years however, alternative detection methods have been emerging which offer different approaches especially for microfluidic systems with applications in point-of-care diagnostics. In this presentation, we will focus on two approaches: a) the integration of silicon photonic devices (so-called PICs) which utilize the semiconductor fabrication methods for silicon but make use of the optical properties of silicon instead of its electronic functionalities and b) the use of ink-jet printed integrated photonic elements such as light-sources and detectors which can be directly integrated in a disposable microfluidic cartridge.

00:00

Amy AdelbergerConference Chair

Title to be Confirmed.
Amy Adelberger, Founder and CEO, Global Impact Advisors, United States of America

00:00

Title to be Confirmed.
Barbara Smith, Assistant Professor, School of Biological and Health Systems Engineering, Arizona State University, United States of America

00:00

Chong AhnKeynote Presentation

Title to be Confirmed.
Chong Ahn, Professor, University of Cincinnati, United States of America

00:00

Paul BohnKeynote Presentation

Multiplex Detection of Sepsis Biomarkers Enabled by Closed Bipolar Electrochemistry with Optical Readout
Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry, University of Notre Dame, United States of America

Sepsis syndrome affects close to 1,000,000 patients annually in the US alone. Of these ca. 30%, predominantly from the pediatric and geriatric populations, do not survive. In current practice, diagnosis is carried out using symptomatic indicators, which is problematic given the similarity of the symptoms to those of patients with influenza. What is needed is a rapid and accurate test that can distinguish where a patient is along the sepsis continuum, starting with systemic inflammatory response syndrome and ending at severe septic shock. We are developing microfluidically-enabled multiplex sensors capable of simultaneously discerning the presence and level of multiple biochemical markers of sepsis syndrome. The sensor relies on a unique assay, in which an electrochemical detection reaction is amplified by redox cycling in an analytical cell. This, in turn, is coupled to a complementary redox-cycled optical readout reaction in a separate reporter cell. Significant flexibility in design means that the readout can be tuned to the desired concentration range of the analyte, colorimetric readout for relatively high level metabolites, e.g. lactate, metal-deposition shifts in optical transmission of metamaterials for higher sensitivity, and fluorigenic reactions where maximum sensitivity is required, e.g. cytokines.

00:00

Bernhard WeiglKeynote Presentation

Title to be Confirmed.
Bernhard Weigl, Director, Center for In-Vitro Diagnostics, Intellectual Ventures/Global Good-Bill Gates Venture Fund, United States of America

00:00

John McDevittKeynote Presentation

Title to be Confirmed.
John McDevitt, Chair, Department Biomaterials, New York University College of Dentistry Bioengineering Institute, United States of America

00:00

Arben MerkoçiKeynote Presentation

Title to be Confirmed.
Arben Merkoçi, ICREA Professor and Director of the Nanobioelectronics & Biosensors Group, Institut Català de Nanociencia i Nanotecnologia (ICN2), Barcelona Institute of Science and Technology (BIST), Spain

00:00

John BrennanKeynote Presentation

Integrating Aptamer Technology with Paper-Based Point-of-Care Devices for Biomedical Monitoring
John Brennan, Professor and Director, Biointerfaces Institute, McMaster University, Canada

DNA aptamers and DNA enzymes (denoted as functional nucleic acids or FNA) are an emerging platform for development of point-of-care (POC) diagnostic devices.  In this presentation, I will first focus on the development of new aptamers and DNA enzymes for a range of key biomarkers and their integration into colorimetric and fluorimetric assays for a variety of targets, mainly in the area of infectious disease.  Methods to couple target-binding to FNAs to the production of a DNA strand as an output will then be described.  The use the output DNA to directly initiate color production or produce isothermal amplification (ITA), will then be outlined.  Finally, the integration of the FNA assays into flow-based paper devices will be described as platform for a range of new POC devices that allow facile detection of clinical analytes.  Examples will be provided outlining paper-based devices for ultra-sensitive detection of E. coli, C. difficile, MRSA and H. pylori.

00:00

Paul YagerKeynote Presentation

Title to be Confirmed.
Paul Yager, Professor, Department of Bioengineering, University of Washington, United States of America


Agenda is not currently available
Add to Calendar ▼2019-10-07 00:00:002019-10-09 00:00:00Europe/LondonPoint-of-Care Diagnostics, Global Health and Biosensors 2019Point-of-Care Diagnostics, Global Health and Biosensors 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com