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SELECTBIO Conferences Flow Chemistry Europe

Flow Chemistry Europe Agenda

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ADME & Predictive Toxicology | Discovery Chemistry Congress | Flow Chemistry Europe  | 

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Tuesday, 18 February 2014




Welcome and Introduction to the Flow Chemistry Society
Ferenc Darvas, Chairman, Flow Chemistry Society, Switzerland


Volker HesselKeynote Presentation

Flow Chemistry - Spotlight on New Activation, Intensification, Integration, and Readiness for Megatrends
Volker Hessel, Professor, Eindhoven University of Technology, Australia


Coffee and Networking in Exhibiton Hall

Material Synthesis and Handling Solids in Flow


Efficient Polymer Synthesis Employing Flow Microreactors
Thomas Junkers, Professor, Hasselt University, Belgium

Precision polymer synthesis in flow microreactors, ranging from synthesis of multiblocks copolymers, modification of endgroups or ligation of polymeric building blocks via click-chemistry approaches is presented and its increased efficiency discussed compared to conventional batch synthesis procedures.


Solids Handling in Microreactors
Simon Kuhn, Associate Professor, Katholieke Universiteit Leuven, Belgium

The talk will present a general inexpensive method for realizing a Teflon stack microreactor with an integrated piezoelectric actuator for conducting chemical synthesis with solid products.


Lunch and Networking in Exhibition Hall


Poster Viewing Session

Catalysis and Biocatalysis


Development of Oxidative Catalysis in Flow
Mimi Hii, Professor, Imperial College London, United Kingdom

In this presentation, the development of heterogeneous catalyst systems for the atom-efficient oxidative transformations of alcohols to carbonyls, amines, esters and amides will be described. The use of both differential and integral reactors to achieve very high selectivity through the manipulation of temperature, stoichiometry and addition rates.


Biocatalytic Transformations in Continuous Flow Reactors: Opportunities Opened up at the Microscale
Bernd Nidetzky, Head of Human and Biotechnology, Graz University, Austria

Enzymes are extremely efficient and highly selective bio-catalysts for chemical synthesis. Flow process development usually involves re-use of enzyme through immobilization. Integration of immobilized enzymes into microstructured reactors are described, and opportunities opened up by smart flow biocatalytic processing are discussed.

Process Validation and Control


Biotransformations in Two-liquid Phase Systems at the Microreactor Scale
Polona Žnidaršic Plazl, Professor, University of Ljubljana, Slovenia

Implementation of microstructured reactors offers several benefits for biotransformation processes in two-liquid phase systems. Selected enzymatic reactions performed in microreactors of various designs yielding various fluid flow regimes will be presented.


Coffee and Networking in Exhibiton Hall


Water Science and Engineering with Microchemical Systems for Applications in Fine Chemicals and Pharmaceuticals Manufacture
Ryan Hartman, Assistant Professor, The University Of Alabama, United States of America

The presentation highlights aqueous chemical reaction engineering for continuous fine chemicals and pharmaceuticals manufacture. The problem of solids handling will be discussed from two perspectives: i) engineering systems that handle solids and ii) engineering reaction solvents in which inorganic salt by-products remain soluble.


Round Table Discussion
Volker Hessel, Professor, Eindhoven University of Technology, Australia
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

Key areas for Discussion:
- Future Industrial Directions in Flow Chemistry
- Missing Information / Tools / Services; Bottlenecks
- The Role of Flow Separation
- Modular Compact Plants and Flow - Something in Common?

The discussions will be held in the Exhibition Hall.


End of Day One

Wednesday, 19 February 2014


Paul WattsKeynote Presentation

Micro, Meso or Continuous Flow Reactors: Which Technology is Best for You?
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

Different microfluidic and meso scale flow reactors will be compared to address how industry can adopt flow reactor technology efficiently.


Coffee and Networking in Exhibiton Hall

Flow Synthesis and Production


Continuous Flow to Scale-up Hazardous Reactions
Christian Stevens, Senior Full Professor, Ghent University, Belgium

The lecture will focus on various reaction types that benefit from continuous processing (exothermic reactions, dangerous reagents, automation of reactions …). Bromination reactions, production of ionic liquids, handling of acid chlorides and toxic gases will be discussed.


Campaign Manufacturing – Smart Production Concepts Through Micro and Milli Quasi-continuous Processes
Stephan Scholl, Institutsleiter/Director, Braunschweig University of Technology, Germany


Lunch and Networking in Exhibition Hall


Poster Viewing Session

Photo and Electrochemistry


Accelerating Photoredox Catalysis in Continuous-Microflow
Timothy Noël, Professor, University of Amsterdam, Netherlands

In this oral communication, we will report on the acceleration of photoredox catalyzed reactions in continuous photomicroreactors.  Relevant examples, such as Stadler-Ziegler reaction and trifluoromethylation reactions, which have been developed in our group will be discussed in more detail.  Insight information will be provided about the discovery process and the different parameters that led to success.


Towards Scalable Photochemical Reactions in Continuous Flow
David Cantillo, Researcher, Graz University, Austria

This presentation will focus on the application of continuous flow photochemistry to the development of an efficient and scalable bromination of benzylic compounds as well to the a-trifluromethylation of ketones.


Coffee and Networking in Exhibiton Hall


Flow Chemistry Today: Towards Multistep Processes and Inline NMR Analysis
Floris Rutjes, Professor, Radboud University Nijmegen, Netherlands

The lecture will focus on integrating several unit operations in a single flow system, including enzymatic transformations. Furthermore, simultaneous inline analysis using flow NMR techniques will be highlighted.


Transport Phenomena of Two-phase Flows in a Microreactor: On-line Model Validation
Igor Plazl, Professor, University of Ljubljana, Slovenia

Azobenzene concentration profiles in multiphase microflows inside microchannels were measured with optimized thermal lens microscope (TLM) technique. A detailed description of the transport phenomena by means of mathematical modeling is presented and validated by on-line measurements.


Close of Conference

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