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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Europe 2020

Lab-on-a-Chip and Microfluidics Europe 2020 Agenda

Co-Located Conference Agendas

Lab-on-a-Chip and Microfluidics Europe 2020 | Organ-on-a-Chip, Tissue-on-a-Chip & Organoids Europe 2020 | Point-of-Care, Biosensors & Mobile Diagnostics Europe 2020 | 

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Wednesday, 9 September 2020


Conference Registration, Materials Pick-Up, Morning Coffee and Tea

Session Title: Conference Opening Plenary Session

Plenary Session Venue: Jurriaanse Zaal, de Doelen Conference Center

Plenary Session Chairpersons: Professors Nicole Pamme and Thomas Laurell


Amy  ShenKeynote Presentation

Glioma on Chips: Analysis of Glioma Cell Guidance and Interaction in Microfluidic-Controlled Microenvironments Enabled by Machine Learning
Amy Shen, Professor, Okinawa Institute of Science and Technology, Japan

In biosystems, chemical and physical fields established by gradients guide cell migration, which is a fundamental phenomenon underlying physiological and pathophysiological processes such as development, morphogenesis, wound healing, and cancer metastasis. Cells in the supportive tissue of the brain, glia, are electrically stimulated by the local field potentials from neuronal activities. How the electric field may influence glial cells is yet fully understood. In this talk, I will present some recent research activities in my group to probe how electric fields in the microenvironment affect the migration of glioblastoma cells by using a versatile hybrid microsystems. To accurately analyze label-free cell migration, a machine learning software, Usiigaci, is developed to automatically segment, track, and analyze single cell movement and morphological changes under phase contrast microscopy. The hybrid microfluidic tools can enable us to elucidate fundamental mechanisms in the field of the tumor biology and regenerative medicine.


Lorena DiéguezKeynote Presentation

Using Microfluidics for Non-Invasive Cancer Diagnosis
Lorena Diéguez, Leader of the Medical Devices Research Group, INL- International Iberian Nanotechnology Laboratory, Portugal

Microfluidics presents numerous advantages for the handling of biological samples, as it provides careful control of fluids in the microscale. When it comes to biomarkers enrichment, microfluidics has demonstrated superior sensitivity and enhanced recovery compared to traditional methods. Incorporating sensors, lab-on-a-chip technologies offer efficient characterization of disease biomarkers from body fluids, making microfluidics ideal for clinical practice, enabling high throughput, portability, and automation. Early dissemination of cancer is difficult to detect by traditional imaging and pathological methods. While the presence of cancer material in body fluids is well known, current techniques for the isolation, analysis and characterization of these biomarkers are not efficient enough to be fully applied in clinical routine. In this talk, we present our work for isolation and multiplex analysis of cancer biomarkers from body fluids based on microfluidics, and biosensors towards personalized medicine and earlier diagnosis of cancer.


Robert VriesKeynote Presentation

Novel Organoid Models to Develop Drug Treatment Strategies
Robert Vries, CEO, Hubrecht Organoid Technology (HUB), Netherlands

Organoids such as IPSC derived brain organoids (Lancaster et al Nature 2013) or our adults epithelial stem cell derived organoids (Sato et al., Nature 2009, 2011) are proving to be a major breakthrough in preclinical models. The new patient like models are fundamental change in the way drug discovery and development can be performed. The development of the HUB Organoids started in the lab of Hans Clevers with the discovery of the identity of adult stem cells in human epithelial tissues such as intestine and liver (Barker et al., Nature 2007; Huch et al., Nature 2013). With the identification of these stem cells, we were able to develop a culture system that allowed for the virtually unlimited, genetically and phenotypically stable expansion of the epithelial cells from animals including humans, both from healthy and diseased tissue (Sato et al., Nature 2009, 2011; Gastroenterology 2011; Huch et al., Nature 2013, Cell 2015; Boj et al., Cell 2015).

We have now generated HUB organoid models from most epithelial organs. Recently, we and others have demonstrated that the in vitro response of organoids correlates with the clinical outcome of the patient from which the organoid was derived (Dekkers et al., Sci Trans Med 2016; Sachs et al., Cell 2018; Vlachogiannis et al., Science 2018). In addition, we have developed a coculture system using HUB Organoids and the immune system to study this interaction and drugs that target the role of the immune system in cancer and other diseases.

We have recently developed new models to study intestinal and lung barrier function and transport of the epithelium of these organs. These experiments show how organoids can be used to study mechanism that underly barrier function disruption in IBD or COPD. Furthermore, we have developed new models to study the interaction between immune system and epithelium. The combination of the new coculture models and assay development to study the epithelium allows us new insights into disease mechanisms and drug treatment strategies.


Morning Coffee Break and Networking in the Exhibit Hall


Valérie TalyKeynote Presentation

Droplet-based Microfluidics for Cancer Research
Valérie Taly, CNRS Research Director, Group leader Translational Research and Microfluidics, University Paris Descartes, France

Droplet-based microfluidics has led to the development of highly powerful tools with great potential in High-Throughput Screening where individual assays are compartmentalized within aqueous droplets acting as independent microreactors. Thanks to the combination of a decrease of assay volume and an increase of throughput, this technology goes beyond the capacities of conventional screening systems. Added to the flexibility and versatility of platform designs, such progresses in the manipulation of sub-nanoliter droplets has allowed to dramatically increase experimental level of control and precision. The presentation will aim at demonstrating through selected example, the great potential of this technology for biotechnology and cancer research. A first part of the presentation will exemplify how microfluidic systems can be used to compartmentalize and assay various types of cells without deleterious effects on their viability within complex and controlled platforms. The application of microfluidic systems for different cell-based assays will be demonstrated. Illustrative examples of droplet-based microfluidic platforms with high potential impact for cancer research will be presented. We will also show how by combining microfluidic systems and clinical advances in molecular diagnostic we have developed an original method to perform millions of single molecule PCR in parallel to detect and quantify a minority of target sequences in complex mixture of DNA with a sensitivity unreachable by conventional procedures. To demonstrate the pertinence of our procedures to overcome clinical oncology challenges, the results of clinical studies will be presented.


Emmanuel DelamarcheKeynote Presentation

Self-Coalescing Flows: A Powerful Method For Integrating Biochemical Reactions In Portable Diagnostic Devices
Emmanuel Delamarche, Manager Precision Diagnostics, IBM Research - Zürich, Switzerland

Diagnostics are ubiquitous in healthcare because they support prevention, monitoring, and treatment of diseases. Specifically, point-of-care diagnostics (POCDs) are particularly attractive for identifying diseases near patients, quickly, and in many settings and scenarios. POCDs can also trace exposure and acquired immunity of populations exposed to infectious diseases and screen metabolic deficiencies of individuals, who may be exposed to severe drug side effects. However, a long-standing challenge with POCDs is the need to integrate reagents in closed devices for a large number of potential applications. Following our previous contributions on developing capillary-driven microfluidic chips for highly miniaturized immunoassays, controlling and monitoring flow with nanoliter precision, and securing diagnostics against counterfeiting with dynamic optical security codes, we recently demonstrated how to shape and fold liquids inside microfluidic chambers to dissolve reagents with extreme precision. In this presentation, I will explain the underlying concept of this method, called self-coalescing flows, and will illustrate how it can be used to perform various assays, ranging from enzymatic assays, to immunoassays and molecular assays. Despite self-coalescing flows being still an open research topic in fluid physics, their implementation is surprisingly facile and robust and therefore may benefit the entire community working on POCDs.


Regina LuttgeKeynote Presentation

Nervous Systems-on-a-Chip: From Technology to Applied Biomedical Sciences
Regina Luttge, Professor, Eindhoven University of Technology, Netherlands

Challenges in eavesdropping on the complex cell signaling of the human central nervous system is an essential driver for the development of advanced in vitro technologies, called Brain-on-a-Chip. Developments in Brain-on-a-Chip technology focus primarily on the implementation of cortical cells from human stem cell source in a 3D cultured microenvironment. The aim of a recently launched EU project CONNECT is to mimic the in vivo functions of the nervous system in one connected chip system. The creation of new neurodegenerative disease models in this project brings together the knowledge accumulated among neuroscientists, stem cell experts and engineers to investigate the origins and possible treatments for Parkinson's disease. In this presentation, we will discuss in detail the technical approach of a nervous system on a chip as a unique tool for modelling the neural pathway of connected tissues on the brain-gut axis. In addition to design criteria for these microliter-sized physiological cell culture systems, the presentation will focus on guidance of the growth process of axon protrusions and the local control of cell differentiation processes while maintaining physiological conditions.


Networking Lunch in the Exhibit Hall, Exhibits and Poster Viewing

Session Title: Current Themes and Trends in Microfluidics Research


Moran BercoviciKeynote Presentation

Diffusion-based Separation Using Bidirectional Electroosmotic Flow
Moran Bercovici, Associate Professor, Faculty of Mechanical Engineering; Head, Technion Microfluidic Technologies Laboratory, Technion, Israel Institute of Technology, Israel

We present a microscale separation method that leverages bidirectional flow, generated by an array of alternate-current field-effect electrodes, to electroosmotically tune the dispersion regime of molecules and particles. Under bidirectional flow the relative motion of species due to differences in their molecular diffusivity can be significantly enhanced.  The system can be configured so that low diffusivity species experience a ballistic transport regime and are advected through the chamber, whereas high diffusivity species experience a diffusion dominated regime with zero average velocity and are retained in the chamber.  We experimentally demonstrate the separation of particles, antibodies, and dyes, and present a theoretical analysis of the system, providing engineering guidelines for its optimal design and operation. This method provides means for leveraging molecular diffusivity for analysis and sample preparation applications, particularly for sub-microliter sample volumes that are not compatible with standard separation techniques.


Boston Micro Fabrication (BMF)How 3D Printing Small Parts Can Deliver Large Value
John Kawola, CEO, Global Operations, Boston Micro Fabrication (BMF)

Recent advancements in additive manufacturing have focused printing larger and larger parts, but many of the world’s products are getting smaller and smaller. One major limitation in the trend towards smaller products is the inability to use traditional manufacturing methods to cost effectively prototype and produce the small parts. Learn how a unique process called Projection Micro Stereolithography (PµSL) for 3D printing is creating true microstructures with ultra-high printing resolution (2µm~50µm) and printing tolerance (+/- 10µm ~ +/- 25µm).


Carl MeinhartKeynote Presentation

Free-Surface Microfluidics and SERS for High Performance Sample Capture and Analysis
Carl Meinhart, Professor, University of California-Santa Barbara, United States of America

Nearly all microfluidic devices to date consist of some type of fully-enclosed microfluidic channel. The concept of ‘free-surface’ microfluidics has been pioneered at UCSB during the past several years, where at least one surface of the microchannel is exposed to the surrounding air.  Surface tension is a dominating force at the micron scale, which can be used to control effectively fluid motion. There are a number of distinct advantages to the free surface microfluidic architecture.  For example, the free surface provides a highly effective mechanism for capturing certain low-density vapor molecules.  This mechanism is a key component (in combination with surface-enhanced Raman spectroscopy, i.e. SERS) of a novel explosives vapor detection platform, which is capable of sub part-per-billion sensitivity with high specificity.


Afternoon Coffee Break in the Exhibit Hall


STRATEC Consumables GmbHHIGH QUALITY PROTOTYPING as a Bridge to Product Development at STRATEC Consumables
Matthias Mösl, Team Leader Protowerk , STRATEC Consumables GmbH

The vast majority of developmental projects for life science and IVD applications require early prototyping. Therefore, the early involvement of injection molding companies like STRATEC Consumables, is becoming more and more important. STRATEC’s focus is on providing an outstanding quality of micro- and nanostructures as well as enabling a smooth transition from early prototyping to mass manufacturing later on. This is supported by specialized design workshops, clearly defined processes applications and sophisticated materials, which are suitable for subsequent mass manufacturing.


Manipulating Liquids with Shaped Acoustic Fields – Applications In Medical Diagnostics and Drug Delivery
Jonathan Cooper, The Wolfson Chair of Bioengineering, University of Glasgow, United Kingdom

Recently, pressure driven flow through the use of surface acoustic waves (SAWs) has attracted much attention.  To better control the nature of the acoustic field when using SAWs, we have introduced the concept of using frequency dependent periodic arrays known as phononic crystals within microfluidics. In doing so, we have enabled new "acoustic holograms" that result in waveguiding, reflectors, bandgaps and lenses, that shape the ultrasonic field and create new microfluidic flows.  We are able to demonstrate how we can create interesting new  fluidic phenomena including the creation of liquid lenses, enabling the imaging of nanoparticles, including viruses, using a mobile phone camera. This level of precise control over liquid flows has also opened up other fields of study including new applications in drug delivery and diagnostics.


Microfluidic ChipShopSense and Sensibility: A Tale of Complexity in Commercial Microfluidic Device Production
Holger Becker, Chief Scientific Officer, Microfluidic ChipShop


Networking Reception with Beer and Wine in the Exhibit Hall -- Meet Exhibitors, View Posters and Network with Colleagues


Close of Day 1 of the Main Conference

Thursday, 10 September 2020


Morning Coffee and Networking in the Exhibit Hall

Session Title: Where is the Microfluidics Field Heading? Commercial Opportunities in the Field


Nicole PammeConference Chair

Microfluidics In Resource-Limited Settings
Nicole Pamme, Professor in Analytical Chemistry, The University of Hull, United Kingdom

Our research centers on the study of microfluidic lab-on-a-chip devices applied to environmental analysis, biomedical research and the synthesis of smart materials. Microfluidic devices offer the possibility for in-the-field and point-of-care analysis provided the devices are portable, require only minimal external instrumentation and little power and are robust. In our group, we are investigating a simple magnetic particle based extraction method, IFAST (immiscible filtration based on surface tension), for pathogen isolation from clinical and environmental matrices in collaboration with researchers in South Africa and Kenya. Furthermore, as part of an EU-funded project (Sullied Sediments) we are developing paper microfluidic devices for on-site measurement of water quality markers such as phosphate. These are being tested by members of the general public who upload data via a custom-built up for data collection with high spatial and temporal resolution.


Has COVID-19 Reshaped the Microfluidics Industry?
Sébastien Clerc, Technology & Market Analyst, Microfluidics & Medical Technologies, Yole Développement, France

The past few months have seen a new biological threat, the COVID-19 infection, caused by the SARS-CoV-2 virus, reshape the entire diagnostics ecosystem. Indeed, the need for respiratory pathogen testing has risen sharply while entire countries lockdown has resulted in a decline in other medical procedures and diagnostics. There have obviously been some winners and some losers in the field. What has the effect of the pandemic been on the microfluidics industry in particular? In this talk, Sébastien Clerc will explain Yole’s vision of how the virus has opened up new opportunities for diagnostics companies, and explain what the impact is for microfluidic companies at different levels of the supply chain and what it could be on the short and long-term future.


Thomas LaurellConference Chair

Title to be Confirmed.
Thomas Laurell, Professor, Lund University, Sweden


Hsueh-Chia ChangKeynote Presentation

Fractionation and Isolation of Exosomes and other Nanocarriers of Molecular Biomarkers
Hsueh-Chia Chang, Bayer Professor of Engineering, University of Notre Dame, United States of America

It is now known that most proteins and nucleic acid biomarkers in the blood and other physiological fluids are encased in a large variety of nanodimension carriers, which are lipid vesicles or protein-nucleic acid complexes.  There is also evidence that such vesicles and complexes inherit the membrane biomarkers of their cells of origin.  Moreover, even within the same cell, different molecules are packaged into different nanocarriers before they are released.  Consequently, whose-sale assay of all the biomarkers would not allow us to accurately quantify their irregular expression in specific cells, such as cancer cells from a particular organ. Current nanocarrier fractionation technologies by ultra-centrifugation, precipitation, size-exclusion, nanofiltration and immunocapture, however, have too low a yield and selectivity,  because of lysing, aggregation, non-selective isolation and other issues. Instead, we report several new fractionation and isolation technologies, based on their size, charge and surface proteins. The key issues are analyzed and resolved, with new inventions based on fundamental principles in nanofluidics, electrokinetics and paramagnetics, to offer significantly higher yield (>90%), selectivity (>95%) and throughput (<1 hour).  We will also report several new molecular sensors that will be integrated with the nanocarrier fractionation technologies for rapid (<30 min) and low-copy number (~100) quantification of multiple molecular biomarkers from the nanocarriers. Our overarching goal is to build a turn-key platform for profiling of multi-biomarkers in a large number of samples.


Morning Coffee Break and Networking in the Exhibit Hall


An Open Platform Concept for Boosting Innovation and Commercialization of Lab-on-a-Chip
Jens Ducree, Professor of Microsystems, Dublin City University, Ireland

Despite a tremendous boost of innovation, many microfluidic “Lab-on-a-Chip” technologies still struggle to arrive at the widespread commercial success that has already been heralded back as far back as the 1990s. As they often address smaller niche markets, Lab-on-a-Chip technologies often fail to tap into economy-of-scale effects which are vital for reaching high Technology Readiness Levels (TRLs) at costs (per device) that are acceptable within a competitive landscape. By adopting lessons from other, technologically rapidly advancing, mature industries like automotive or electronics, we propose an open platform approach based on sharing a standardised architecture including a library of geometrically parametrized, designed-for-manufacture fluidic modules, simulation and characterization tools to stimulate the formation of multi-party supply chains including foundries and services. System integrators can thus focus on honing their unique selling points (USPs) based on their key enabling intellectual property, e.g., in terms of the assay, reagents, transduction schemes, to substantially accelerate and de-risk their product development path.


Preco, Inc.Scaling Up for High Volume Chip Production
Chris Walker, Director, Microfluidics & Medical Converting Equipment Markets, Preco, Inc.

The benefits of working in automated LOC production are presented, using the method of compiling polymer foil/film and adhesive substrates, and with the equipment employed for increasing rates of manufacture. While microfluidics chip design development has matured tremendously in regard to technique, a sober side is shown, as concept prototype designs grow into a greater number of promising test platforms and onward to high-volume customer orders.


Andrew J deMelloKeynote Presentation

Ultra-High-Throughput Multi-Parametric Imaging Flow Cytometry
Andrew J deMello, Professor of Biochemical Engineering & Institute Chair, ETH Zürich, Switzerland

I will present recent activities aimed at developing novel microfluidic imaging flow cytometers for blur-free cellular analysis at throughputs exceeding 100,000 cells per second. By combining passive (inertial or viscoelastic) focusing of cells in parallel microchannels with stroboscopic illumination, such chip-based cytometers are able to extract multi-colour fluorescence and bright-field images of single cells moving at high linear velocities. This in turn allows accurate sizing of individual cells, intracellular localization and analysis of heterogeneous cell suspensions. The methods are showcased through the rapid enumeration of apoptotic cells, high-throughput discrimination cell cycle phases and localization of p-bodies.


Noah MalmstadtKeynote Presentation

Title to be Confirmed.
Noah Malmstadt, Professor, Mork Family Dept. of Chem. Eng. & Mat. Sci., University of Southern California, United States of America


Networking Lunch in the Exhibit Hall and Networking with Exhibitors


Poster Viewing Session


Microdrop Technologies GmbHPrecise Contactless Spotting for Lab-on-Chip Applications
Wilhelm Meyer, Managing Director, Microdrop Technologies GmbH

Lab-on-chip devices are used for a wide variety of health care applications, especially in the area of point-of-care diagnostics. These small microfluidic devices equipped with microchannels, chambers and other features carry out diagnostic tests by enabling reactions between patient samples and reagents. The devices deliver test results with very small sample volumes and in a short period of time. For production of lab-on-chip devices a precise and fast material deposition method is needed. Typically, the devices are produced at high numbers under high throughput conditions. The substrates may be made of different materials e.g. polystyrene or silicone, but in common is that these substrates typically have a structured surface which may consist of channels, mixing chambers or even wells which are used for precise detection. Also, different coating materials may be used as pretreatment for better adhesion of reagents or confinement of fluids. Deposition or Spotting of reagents onto the chip is a demanding task and requires the filling of small cavities and microchannels with a high accuracy. This can efficiently be done with a microspotting platform based on in inkjet technology. The flexibility of this technology allows for custom-made solutions adapted to the specific customer needs. Especially how high accuracy concerning volume of spotted reagents and also precision of placement is achieved under high throughput production conditions is demonstrated by examples.


Holger SchmidtKeynote Presentation

Advanced Single Molecule Analysis on a Chip
Holger Schmidt, Narinder Kapany Professor of Electrical Engineering, University of California-Santa Cruz, United States of America

Optofluidic devices have emerged as the basis for ultra-sensitive, amplification-free analysis of single molecules. We will describe the core features and capabilities of this approach and discuss recent advances in the areas of novel molecular targets, assay and signal optimization, and signal analysis techniques.


Production of Spinnerets for Microfluidic Spinning of Biocompatible Microfibers with In-situ Direct Laser Writing
Matthias Geiger, Research Scientist, RWTH Aachen University, Germany

A method for the production of spinnerets for microfluidic wet-spinning of micron-sized fibers has been developed. Biocompatible, mechanically strong microfibers suitable for cell culture were produced from regenerated silk with precise diameter control.


Recent Developments and Applications of Centrifugal Microfluidics
Nils Paust, Head of Division Microfluidic Platforms, Hahn-Schickard-Gesellschaft für Angewandte Forschung eV, Germany

In this talk I will give an overview of recent developments in research, and in the fields, the platform technology of centrifugal microfluidic is applied to. Research at our lab focuses on system integration. Addressed applications range from library preparation for next generation sequencing via integrated analysis from swab sample to digital amplification to fast point-of-care testing of SARS-Cov-2.


Bio-Inspired Microfluidic Flow Control for Lab-on-a-Chip
Jaap den Toonder, Professor and Chair of Microsystems, Eindhoven University of Technology, Netherlands

Control of fluid flow at small length scales (typically < 1 mm) i.e. “microfluidics”, is important for many applications. Examples are Lab-on-a-Chip devices for healthcare diagnostics, in which complex tasks of (bio-)fluid manipulation and detection need to be performed. We are developing new technologies for active control of microfluidic flow. In doing this, we are inspired by nature in which a variety of microfluidic manipulation principles can be recognized. In this talk, I will show:

  • Artificial cilia: biomimetic micro-actuators inspired by natural cilia, which are microscopic hairs covering the surface of micro-organisms like paramecium, providing propulsion
  • Evaporation + capillary driven micropumping, inspired by fluid transport in plants and trees
  • Static and dynamic surface topographies for fluid mixing and droplet manipulation, based on responsive materials, and inspired by bio-surfaces of lotus leaves and sharks
I will present the basic ideas, the materials and processes developed to translate the ideas into a technology, and the microfluidic flow control they make possible.


Hydrodynamic Confinements: An Enabling Bioanalytical Technology for Tumor Profiling
Govind V Kaigala, Research Staff Member, IBM Research Laboratory-Zurich, Switzerland

Traditionally, compartments are formed with hydrogels, multi-phase systems (droplets), or inkjets for interrogating biological systems. In contrast, we are developing ‘flow confinements’ which comprise compartments formed on a surface by the flow of a shaping liquid around a processing liquid. We termed these implementations collectively as tunable flow confinements (TFC). In contrast to standard microfluidics, which are typically closed, we are developing scanning, non-contact microfluidic technologies that can dynamically shape liquids in the "open space" over surfaces. TFCs are implemented using a liquid scanning probe called the microfluidic probe and function on standard biological substrates such as Petri dishes, slides, and tissue sections when the substrate is kept wet. In this talk, I will show how this family of liquid scanning probe devices is evolving as a versatile bioanalytical tool. I will also propose concepts pertaining to tissue microprocessing encompassing local phenotyping and molecular profiling, which may contribute to the multi-modal analysis of critical biopsy samples and conclude with a few possibilities beyond medical applications.


On-Line Visualization of Colloidal Filter Cake Motions
Arne Lüken, Researcher, Aachen University, Germany

Membrane ultrafiltration is a low-energy unit operation for soft matter or colloid purification. This process suffers from the agglomeration of the filtrated matter on the surface of the membrane, the so-called gel layer or filter cake. This undesirable cake layer rises the resistance for the fluid permeating the membrane, and thus, increases the energy consumption of the process. In this study, the authors visualize the motion of a soft colloid cake layer using laser scanning confocal microscopy inside a microfluidic filtration module. They analyze the filter cake’s organization and its dynamic motion while performing widely applied cleaning strategies, such as backflushing and crossflow flushing. They present the inner organization of the cake and find responsive 3D-motions of the filter cake under shear stress. This unique cake behavior suggests new strategies for filtration processes and additionally demonstrates the potential of applying microfluidic analysis methods to macroscopic research fields.


Poster Awards


Close of Day 2 of the Conference

Add to Calendar ▼2020-09-09 00:00:002020-09-10 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2020Lab-on-a-Chip and Microfluidics Europe 2020 in Rotterdam, The NetherlandsRotterdam, The