08:00 | Registration and Continental Breakfast |
|
Session 1 |
| Session Chair: Aaron Beeler, Assistant Professor, Boston University, United States of America |
| |
09:00 | Welcome Remarks from Chair of the Flow Chemistry Society
Ferenc Darvas, Chairman, Flow Chemistry Society, Switzerland
|
09:15 |  | Keynote Presentation Hazardous Chemistry Meets Microreactors
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria
Contributions from our research group in the field of continuous flow processing will be highlighted. Emphasis will be given to highly atom efficient and process intensified chemical transformations useful for the synthesis of APIs or key intermediates that are often too hazardous to be executed in a batch reactor. These involve azide, diazomethane and nitration chemistry, selective precious metal-free olefin and nitrogroup reductions. |
|
10:00 | Recent Flow Chemistry Applications in Industry
Heather Graehl, Director of Sales North America, ThalesNano, United States of America
Thalesnano is the industry leader of continuous flow reactors and works closely with industrial and academic customers in enabling research and manufacturing across the globe. Recent results from Thalesnano internal R&D as well as external projects will be highlighted. |
10:30 | Coffee and Networking in Exhibition Hall |
11:00 | Expanding Possibilities for Compound Library Generation in Flow with Immobilized and Exchangeable Reagents
Noah Tu, Senior Scientist, Abbvie Inc, United States of America
A custom-built modular flow reactor has been developed to support our compound library production in integrated flow-purification platforms. This reactor opens the way to chemical transformations previously not readily achievable with our flow chemistry systems. |
11:30 | The Medicines for All Initiative: A Flow-based Synthesis of Nevirapine
Frank Gupton, Floyd D. Gottwald Chaired Professor, Virginia Commonwealth University, United States of America
A continuous process has been developed for nevirapine, the active ingredient in a widely prescribed treatment of AIDS. The new process includes the continuous preparation of the two key pyridine precursors. |
12:00 |  Technology Spotlight:
Recent Progress in Microwave Flow Reactor Technology
Akira Tomita, President, Pacific Microwave Technologies
We discuss a new compact microwave flow reactor and its key benefits in organic synthesis. The process conditions can be optimized quickly, and stable operation over 1000 cycles at ~Kg/day production level has been demonstrated.
|
12:15 | Lunch and Networking in Exhibition Hall |
13:30 | Poster Viewing Session |
|
Session 2 |
| Session Chair: Frank Gupton, Floyd D. Gottwald Chaired Professor, Virginia Commonwealth University, United States of America |
| |
14:00 |  | Conference Chair Photochemical Reactions in Flow
Aaron Beeler, Assistant Professor, Boston University, United States of America
This lecture will focus on the development of a flow photochemical platform and a number of photochemical reactions that have been explored in the Beeler Research Group. |
|
14:45 | Continuous-flow Synthesis in Milli-reactors using Microwave Heating
Lubabalo Mafu, Research Scientist, Nelson Mandela Metropolitan University (NMMU), South Africa
We report a microwave-assisted continuous-flow synthesis of di-ester derivatives. The method involves a combination of a milli-reactor operation and microwave heating as an energy source. This combined strategy allows one to have an accurate control over the reaction temperatures and substrate residence times. Moreover, it also employs a polymer-supported scandium triflate (PS-Sc(OTf)3) as an environmentally friendly catalyst. |
15:15 | Coffee and Networking in Exhibition Hall |
16:00 | ADC Synthesis in Flow
Graham Jones, Professor/Head, Northeastern University, United States of America
The use of continuous flow technology for the synthesis of protein bioconjugates will be presented. In addition to reagent proteins, monoclonal antibody conjugates will also be highlighted. |
16:30 | Flow Reactors with Polymeric Membranes for Catalytic Aerobic Partial Oxidation Chemistry in Pharmaceuticals and Specialty Chemicals
Thatcher Root, Professor of Chemical and Biological Engineering, University of Wisconsin, United States of America
Polymer-based membranes using inexpensive,
commodity tubing enable implementation of catalytic aerobic oxidation in flow.
Matching gas permeation with reaction kinetics allows safer use of elevated
oxygen pressures while avoiding solvent flammability concerns. |
17:00 |  Drinks Reception
|
