Thursday, 6 October 2022

08:00

Conference Registration, Materials Pick-Up, Morning Coffee and Tea


Session Title: Conference Opening Session -- Flow Chemistry Asia 2022

09:00

Paul WattsConference Chair

Continuous Flow Drug Manufacturing in Africa
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

While Africa has a variety of companies that formulate medicines it has very little active pharmaceutical ingredient (API) manufacturing, with the consequence that these need to be imported. This results in increased drug costs, making medications unaffordable to most patients in Africa.  Economic, social and political stresses have been witnessed all over the world during the COVID-19 pandemic. In particular, drug shortages and inaccessibility is one of the many results of disruption of supply chains due to the shutdown of manufacturing activity, as well as export restrictions and bans by other countries. To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. A selection of examples will be presented.

09:30

Thomas WirthKeynote Presentation

Intensification and Electrification of Flow Chemistry
Thomas Wirth, Professor, Cardiff University, United Kingdom

The advantages of increased mixing of biphasic reaction mixtures in flow offers great potential compared to conventional flask techniques, especially when combined with microwave irradiation or phase transfer catalysis. The presentation will also illustrate that metal-catalyzed reactions and enzyme-promoted transformations can be performed advantageously in biphasic systems. The development of a microreactor for electrochemistry including several applications will be discussed.

10:00

Stoli ChemCSTR Series: Where Usual Chemistry Does Not Flow
Nikolay Cherkasov, Managing Director, Stoli Chem

Conventional flow reactors such as tubes and chips are excellent. Their scaling up, however, is difficult because fluid velocity determines residence time, pressure drop, and mixing/heat transfer. CSTRs, on the other hand, provide mixing independent of flow rates and could handle exothermic, multiphase, and reactions with solids. We discuss case studies where such capabilities improve process throughput and yield.

10:30

Mid-Morning Coffee, Tea and Networking in the Exhibit Hall

11:00

SyrrisHow Flow Chemistry Can Impact the Early Drug Discovery Process?
Andrew Mansfield, Flow Chemistry Leader, Syrris

Flow chemistry is a growing technology in the pharma industry, where it has proved itself invaluable, especially in the process development phase of drug discovery. However, the hit-to-lead and lead-generation phases have been slower to embrace these techniques. The potential benefits are huge, particularly for rapid library generation and challenging chemistries that were previously hard to achieve by traditional batch methods. The content of this presentation looks at how researchers in early drug discovery, who are looking for practical and efficient ways to increase their productivity and shorten the hit-to-lead times can achieve this through the use of flow chemistry techniques.

11:30

Fuji-TechnoTriplex Plunger-driven Diaphragm Pumps
Taro Yanagiuchi, Sales Manager, Fuji-Techno

We will be presenting two new offers to our portfolio. 1st our newly developed diaphragm pump, which unlike others, can handle a vast majority of slurry liquids. 2nd our AI software which further minimizes pulsation thru AI learning of the pulsation patterns and adjusting the motor speed. In the introduction, we will explain the operating principles, performance, benefits of our innovative products.

12:00

Networking Lunch in the Exhibit Hall -- Visit Exhibitors and View Posters -- Japanese Bento Box Lunch


Session Title: Flow Chemistry Asia 2022 -- Emerging Trends in Flow Chemistry Session

14:00

Micro-Flow Synthesis of Specialty Peptides
Shinichiro Fuse, Professor, Nagoya University, Japan

Amide bond formation via generation of highly electrophilic species was developed. Undesired reactions were successfully suppressed by using micro-flow technologies.  The developed approach was used for synthesis of specialty peptides.

14:30

Incorporative Mixing in Microreactors: Influence on Reactions and Importance of Inlet Designation
Shusaku Asano, Assistant Professor, Kyushu University, Japan

We studied the mixing in a microreactor considering fluid division and incorporation. Incorporative mixing occurs when a divided feed stream is taken into another stream. Reaction selectivity is sensitive to incorporative mixing. Thus, the change in the feed orientation of inlets significantly changes the reaction outcome.

15:00

Flow Chemistry and Reaction Engineering - Application to the Synthesis of Neuroprotective Agents
Darren Riley , Associate Professor, University of Pretoria , South Africa

The presentation will focus on the development of end-to-end flow-based synthetic routes to pharmaceuticals with a neurological focus and will include aspects of batch-flow hybridization and reaction engineering. Insight will also be given pertaining to the use of flow technology as a disruptive leap-frogging technology for the localization of pharmaceutical manufacturing in developing countries.

15:30

Mid-Afternoon Coffee and Tea Break and Networking in the Exhibit Hall

16:00

Flow-based Process Development to Support the Localization of Active Pharmaceutical Ingredient Manufacturing in Africa
Jenny-Lee Panayides, Principal Scientist and Research Group Leader, CSIR Biosciences South Africa, South Africa

The presentation will focus on the efforts to adopt flow technology in developing countries for the manufacture of active pharmaceutical ingredients. Case studies will highlight the development of a flow-based route to a non-steroidal anti-inflammatory drug and discuss recent efforts to develop an economical platform for controlling and automating flow equipment.

16:30

Dong Pyo KimKeynote Presentation

Novel Microfluidic Platforms for Scale-Up Production and Autonomous Self-Optimization
Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH), Korea South

Flow chemistry in the confined microfluidic space enables easy up-scaling production at precise controlled conditions. In the talk, we show the assembly of 16 numbering-up 3D printed metal microreactor to render high productivity up to 20 g for 10 min operation of subsecond ultrafast chemistry. And, hexagon-shaped 3D printed polymer module of photomicroreactor with solar concentrator leaded to facile assembly into serial and radial reconfiguration for high throughput of synthesis. In addition, for scalable production of emulsions, compact 3D printed droplet generator was devised by array of 40 drop-makers with a 3D void geometry and a flow distributor, producing microgels and microparticles. Finally, we explore ultrafast flow chemistry by autonomous self-optimizing platform that accelerates the optimization and screening of complex chemistry.

17:00

Shu KobayashiKeynote Presentation

Organic Synthesis Enabled by Catalytic Flow Methods
Shu Kobayashi, Professor, The University of Tokyo, Japan

In synthesis, flow methods have several advantages over batch methods in terms of environmental compatibility, efficiency, and safety. Wastes derived from work-up processes can be minimized or omitted altogether by performing organic transformations in flow. Equipment for chemical manufacturing can be designed to be smaller, which would enable significant savings in space and costs. In addition, the differences between batch and flow reactors, which are the large surface to volume ratios and the rapid mixing/quenching of reagents, should make chemical productions safer and more efficient. While continuous-flow practices have been adopted in the petrochemical and bulk chemical industries, its applications in fine chemical production have been limited. It was believed that synthesis by flow methods could be applicable for the production of simple gasses such as ammonia, but was difficult to apply to the preparation of complex molecules such as active pharmaceutical ingredients (APIs). This lecture will discuss recent advances in organic synthesis enabled by continuous-flow methods. In particular, the development of heterogeneous catalysts in multi-step continuous-flow reactions (sequential flow reactions) for the synthesis of complex organic molecules will be highlighted.

17:30

Close of Programming on Day 1 of the Conference

Friday, 7 October 2022

08:00

Morning Coffee, Tea and Networking in the Exhibit Hall

09:00

Continuous-Flow Self-Supported Electrochemically Mediated Atom Transfer Radical Polymerization Intensified by Sonication
Suqi Zhang, Researcher and PhD Candidate, KU Leuven, Belgium

Electrochemically mediated ATRP (eATRP) has attracted much interest due to its convenience in influencing polymerization behavior externally. This tall will focus on the recent realization of continuous flow eATRP by our group using a novel sonicated microreactor setup. The setup is also further developed into a microreactor cascade by connecting two identical reactors in series. Preliminary results showed the reaction rate was higher and good molecular weight evolution was obtained in most cases.

09:30

Microfluidics and Flow Chemistry In Radiochemistry: A Perfect (Future) Match?
Giancarlo Pascali, Professor, University of New South Wales, Australia

The use of microfluidic systems and flow chemistry was pioneered in radiochemistry in 2004; since then, numerous researchers have shown how using these techniques can provide a much better yield, economy, reliability and safety. This talk will give several examples demonstrating how the unique features of these approaches are a perfect match with the numerous challenges of radiochemistry. However, currently only a small number of commercial synthetic systems adopt these concepts; the last part of this talk will be aimed at proposing some causes for this surprising fact, potentially stimulating useful synergies with the traditional pharmaceutical manufacturing actors.

10:00

Continuous Flow Biocatalytic Production of Rocket Fuel
Michael Spano, PhD Candidate and Researcher, University of California-Irvine, United States of America

Rocket propulsion has largely relied on hydrazine as a hypergolic propellant. Safer and higher performing fuels are replacing hydrazine in the aerospace industry. We draw our attention to one such alternative and show how this target may be synthesized via chemo-enzymatic catalysis in continuous flow.

10:30

Mid-Afternoon Coffee and Tea Break and Networking in the Exhibit Hall

11:00

Rapid Synthesis of Monodisperse Polymer Particles Using Slug Flow
Takaichi Watanabe, Research Associate Professor, Okayama University, Japan

Heterogeneous polymerization in slug flow is found to be a versatile platform to produce monodisperse polymer particles in a short reaction time.

11:30

Volker HesselKeynote Presentation

Flow Synthesis of Phosphorus Nanocomposites for Controlled Fertilizer Release and Wheat Growth
Volker Hessel, Professor, School of Chemical Engineering, The University of Adelaide, Australia

Flow chemistry has shown distinct advantages in the synthesis of nanomaterials. Here, we investigate flow chemistry for the synthesis of nanofertilizers which has been so far less reported in literature. New generations of P fertilizer have been developed in batch synthesis. In 2020, Hessel et al. proposed a process for leaching phosphorus from mimicked moon crust using a re-entrance flow microfluidic device and using this to fertilize lettuce in “space greenhouses”, and recycling phosphate from lettuce root via burning in a furnace.
 
In this research, a coiled inverted flow system, was used to prepare a slow released P-containing fertilizer and this system also allowed the direct adsorption of low molecular weight organic acid anions (LMWOAs). Citrate ions, as the chosen LMWOAs, were incorporated with the above prepared phosphorus fertiliser to form a compound fertilizer capable of releasing nutrients in a slow manner and reducing the P binding sites in P deficient soil. The nutrient performance was investigated in a model soil mixture. The system allowed the one-stage production of LMWOAs adsorbed apatite with the maximum adsorption capacity of 0.19 gcitrate.gaptite-1 in a continuous manner. The presence of citrate ions in the prepared material increased the P availability in the model soil mixture by 2.6 times compared to commercial apatite. After 14 days of application, about 57% of P in the prepared fertilizer was released into the soil solution.  

We will also report about an extension of the approach here towards nanoencapsulation by chitosan and using more innovative continuous-flow reactor equipment, including the Corning and StoliFlow reactors. We will compare the wheat growth efficiency of the flow-made phosphorus nanofertilizers with plasma-made nitrogen (carbon dot and solution-based) fertilizers, which we also prepare.

12:00

Tanja JunkersKeynote Presentation

It's a Machines World: Challenges and Opportunities in Automated Polymer Synthesis
Tanja Junkers, Professor, School of Chemistry, Polymer Reaction Design group, Monash University, Australia

Contemporary macromolecular chemistry has matured to a point where virtually any polymer structure can be synthesized via combinations of controlled polymerization approaches, post-polymerization modification and efficient ligation strategies. Still, often large hurdles have to be overcome to take the next step in research, that is being able to provide such complex materials reliably on significant scale for use in advanced applications. A solution to this problem is to make use of continuous flow synthesis techniques. Flow reactors are associated with high reproducibility, intrinsically simple reaction scale-up and improved product qualities due to significant reduction of side reactions. Being an established method especially in the pharmaceutical chemistry domain, full potential with regards to macromolecular synthesis did not unfold until very recently. Among others, the benefits of using online-monitoring, reactor automation and machine-learning will be discussed and the development of fully autonomous based reactor systems presented. Also polymer self-assembly itself can largely benefit from flow operation, and first advances in this area will be presented. The potential of flow chemistry for preparative macromolecular chemistry will be discussed and explored on the example of polymerization. Further, the possibility to build reactor cascades and the advantages of online-monitoring will be highlighted. Machine-assisted synthesis of polymers is shown to be superior in accuracy in synthesis. Generally, the introduction of smart algorithms in synthesis control opens avenues into the digital chemistry space, and challenges and opportunities in this realm will be discussed.

12:30

Networking Lunch in the Exhibit Hall -- Visit Exhibitors and View Posters -- Japanese Bento Box Lunch

13:30

Continuous-Flow Synthesis of Optically Responsive Nanomaterials
Irina Koryakina, PhD student, ITMO University, Russian Federation

Optically responsive nanoparticles (NPs) have emerged as a highly demanded tool that addresses important issues in biological and optical sensing, imaging, photovoltaics, photothermal therapy, etc. In spite of the developments in emerging nanoparticles (NPs) synthesis approaches, faster and reliable methods for the controllable synthesis of the desired compounds are still highly demanded. Microfluidic synthesis approach allows overcoming the known critical stages in the conventional synthesis of NPs due to the high rate of heat/mass transfer and precise regulation of synthesis conditions, which results in reproducible synthesis outcomes with the desired physico-chemical properties. In the recent work, a novel approach for the synthesis of nanolasers based on lead halide perovskite particles in a microfluidic chip (MFC) was developed. The synthesis procedure allowed for obtaining various morphologies of perovskite particles by tuning the precursors flow ratios. In another work, metal organic frameworks (MOFs) with enhanced surface defects were synthesized by deploying continuous flow regime in an MFC. It was shown that obtained MOF possessed enhanced loading capacities due to the developed surface, which opens up new prospects for the fabrication of improved drug delivery platforms. Therefore, optically responsive NPs (perovskites and MOF) were synthesized in a continuous flow regime in MFC. It was shown that the deployed method enables fine tailoring of physico-chemical properties of nanomaterials through the structural deviations, which can be achieved by manipulation of flow reagents in microchannels.