Emma Shanks's Biography

Emma Shanks, Head of Screening, Beatson Institute for Cancer Research

After completing a PhD at the University of Dundee, I worked in the newly established Drug Discovery Unit in Dundee, developing assays for biochemical and phenotypic screens to support high throughput siRNA and small molecule screens; this work aimed to find new therapies for neglected tropical diseases and novel targets for diseases such as cancer. I currently run a cancer research focused Screening Facility which aims to identify novel drug targets in key pathways and mechanisms, reduce chemotherapeutic drug resistance and side effects, and identify new therapeutics from existing non-cancer drugs. Our own research centres on drug repurposing approaches and identifying novel therapeutics for Head and Neck Squamous Cell Carcinoma (HNSCC)

Strategic siRNA Screening Approaches to Targeting Cancer

Tuesday, 17 September 2013 at 11:30

Add to Calendar ▼2013-09-17 11:30:002013-09-17 12:30:00Europe/LondonStrategic siRNA Screening Approaches to Targeting CancerAcademic Screening Workshop 2013 in Baltimore, MA, USABaltimore, MA, USASELECTBIOenquiries@selectbiosciences.com

The RNAi Screening Facility at the Cancer Research UK Beatson Institute combines genome-wide siRNA screening with High Content Imaging and fluorescence-based phenotypic assays to target cancers derived from multiple tissue types. Permutations of synthetic lethality allow for novel target identification in i) defined genetic cancer backgrounds, ii) chemotherapeutic-resistant cancer lines and iii) in combination with pre-clinical or known drugs. Of central importance to our approach is the use of an appropriate and predictive model that facilitates translation of results towards the clinic, and our experiences with this will be discussed.

Add to Calendar ▼2013-09-17 00:00:002013-09-18 00:00:00Europe/LondonAcademic Screening Workshop 2013Academic Screening Workshop 2013 in Baltimore, MA, USABaltimore, MA, USASELECTBIOenquiries@selectbiosciences.com

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