Dominique PV de Kleijn's Biography

Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands

Prof. Dr. Dominique PV de Kleijn is molecular biologist and chemist and professor of Exp. Vascular Surgery at UMC Utrecht and professor at the Netherlands Heart Institute. From 2012 to 2016, he was Research Professor of Surgery at NUS/NUHS and preclinical director of the Cardiovascular Research Institute (CVRI) Singapore. He was until 2016 professor of Cardiovascular Immunology and co-chair of Experimental Cardiology at UMC Utrecht. Since 1997 he is coordinating cardiovascular research from basic science, animal myocardial infarction and atherosclerotic studies (pig and sheep) towards clinical biobanking studies. His research interests are: The innate immune system in cardiovascular disease and atherosclerosis & Biomarkers predictive for primary & secondary events with a focus on plasma extracellular vesicles. He has more then 275 publications and a H-factor of 78.

Plasma Vesicles Content as a New Sample Type for Clinical Diagnosis and Prognosis of Myocardial Infarction and Stroke

Thursday, 12 September 2013 at 11:00

Add to Calendar ▼2013-09-12 11:00:002013-09-12 12:00:00Europe/LondonPlasma Vesicles Content as a New Sample Type for Clinical Diagnosis and Prognosis of Myocardial Infarction and StrokeExosomes and Circulating Biomarkers Summit 2013 in San Diego, CASan Diego, CASELECTBIOenquiries@selectbiosciences.com

Extracellular vesicles, including microvesicles, microparticles and exosomes are abundant in plasma. All cells secrete extracellular vesicles with release being very rapid after innate immunity activation of inflammatory cells. These vesicles are important in cell-to-cell communication in a variety of processes including coagulation, antigen presentation and tissue damage. Plasma extracellular vesicles can be easily isolated from frozen plasma or serum and contain protein, miRNA and RNA depending on source and stimulus. Isolating these vesicles from the blood and studying their content may provide rapid information on the pathological status of tissues. We showed that plasma vesicles content can be used for the diagnosis of Acute Coronary Syndrome in an emergency department cohort of 471 patient with chest pain. Next to this, we showed that vesicle content in a cohort of 1060 patients can be used for the prognosis of secondary cardiovascular events on top of existing risk factors and are expecting to have a CE certified kit available this year.
We anticipate that plasma extracellular microvesicles in the near future will emerge as an important source for diagnostic and prognostic markers for cardiovascular disease and will help us in understanding the underlying biology.

Add to Calendar ▼2013-09-12 00:00:002013-09-13 00:00:00Europe/LondonExosomes and Circulating Biomarkers Summit 2013Exosomes and Circulating Biomarkers Summit 2013 in San Diego, CASan Diego, CASELECTBIOenquiries@selectbiosciences.com

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