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Roles of Mesenchymal Stem Cell–derived Exosomal Non-coding RNAs in the Oncogenic Potential of Glioma Stem Cells and in microRNA-based Therapy for Glioblastoma

Monday, 23 March 2015 at 16:00

Add to Calendar ▼2015-03-23 16:00:002015-03-23 17:00:00Europe/LondonRoles of Mesenchymal Stem Cell–derived Exosomal Non-coding RNAs in the Oncogenic Potential of Glioma Stem Cells and in microRNA-based Therapy for GlioblastomaSELECTBIOenquiries@selectbiosciences.com

Mesenchymal stromal cells (MSCs) are multipotent stem cells that reside in various tissues such as bone marrow, adipose, placenta and umbilical cord. MSCs are able to cross the blood brain barrier and migrate to and track glioma. Endogenous MSCs derived from bone marrow and adipose tissues have been reported to migrate to tumor sites and promote EMT and metastasis.  We explored the role of exosomes derived from adipose derived MSCs and found that administration of these MSCs or their exosomes increased the self-renewal, stemness markers, mesenhycmal transformation and the migration of glioma stem cells (GSCs). In contrast, cord and placenta-derived MSCs and their secreted exosomes exerted opposite effects and their intracranial administration decreased the tumor growth of GSC-derived xenografts and prolonged animal survival. miRNA sequencing and long non-coding RNA array analyses of these exosomes revealed a set of specific miRNAs and lncRNAs that were downregulated and acted as tumor suppressors in GSCs. Some of these miRNAs were delivered to GSCs following treatments with MSC-derived exosomes and exerted a strong inhibitory effect on the growth of GSC-derived xenograft. The role of exosome-derived miRNAs in the regulation of GSC oncogenic potential, and their clinical applications in stem cell-based glioma therapeutics will be discussed.