Conferences \ Lab-on-a-Chip, Microfluidics & Microarrays World Congress 2016 \ Agenda \ Kennedy Okeyo |
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Step by Step Fabrication of Biomaterials based on Cell Adhesion ControlWednesday, 28 September 2016 at 08:00 Add to Calendar ▼2016-09-28 08:00:002016-09-28 09:00:00Europe/LondonStep by Step Fabrication of Biomaterials based on Cell Adhesion ControlLab-on-a-Chip, Microfluidics and Microarrays World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com On-chip fabrication of biomaterials such as cell sheets based on self-assembly organization of cells into tissues continues to attract attention due to potential applications in regenerative medicine as well as in the development of in vitro models for drug screening. We recently developed a technique for step-by-step fabrication of cell sheets based on adhesion control. It involves minimization of cell-substrate interaction to initiate self-assembly of cells, not into spheroids, but into planar cell sheets which can be then overlaid or stacked into 3D tissue models. For cell adhesion minimization, we developed a mesh culture system where cells are seeded and grown on suspended ultra-thin (~2µm thick) mesh scaffolds consisting of considerably large apertures (exceeding 100 µm in size) and thin mesh lines (3-5 µm in width). |