Marloes Peeters,
Deputy Director of Chemical Engineering,
Newcastle University
Marloes graduated from Eindhoven University of Technology (the Netherlands) with a degree in Chemistry & Chemical Engineering. For her PhD, she moved to research institute IMO/IMOMEC in Belgium where she was part of the BIOSensors group of Prof Wagner. There, together with Maastricht University, she developed polymer-based sensing platforms that were used for the electrochemical and thermal detection of neurotransmitters. After finishing her PhD, she continued as a postdoctoral researcher within the same group to focus on aptamers as recognition elements. In 2014, she started working in the organic chemistry group of Prof Kilburn at Queen Mary University of London. Her independent research commenced at Manchester Metropolitan University in 2015 where she was promoted to senior lecturer in Chemical Biology in 2018. Since March 2019, her group has moved to Newcastle University where she is an associate professor in the School of Engineering and current deputy director of Chemical Engineering. Her research group focuses on developing novel (portable) sensing platforms that can be used in sustainable healthcare.
Smart Thermometers: Screening for Biomarkers Using Molecularly Imprinted Polymers (MIPs) Combined with Thermal Detection
Wednesday, 19 June 2019 at 08:30
Add to Calendar ▼2019-06-19 08:30:002019-06-19 09:30:00Europe/LondonSmart Thermometers: Screening for Biomarkers Using Molecularly Imprinted Polymers (MIPs) Combined with Thermal DetectionPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Molecularly Imprinted Polymers (MIPs) are synthetic antibody mimics: similar to antibodies they possess high affinity for a chosen template molecule. However, they have distinct advantages over their natural counterparts such as low-cost, superior chemical and thermal stability, and straightforward production process. In this contribution, we will discuss the use of nanoMIPs that are synthesized via a solid-phase approach. The high affinity nanoparticles prepared by this technique are water-soluble, meaning it is simple to directly functionalize them onto thermocouples via dipcoating. These functionalized thermocouples were subsequently inserted into a home-made heat-transfer device that measures the temperature of the liquid in a flow cell. It was shown that binding of the target to the MIP layer increased the resistance at the solid-liquid interface, leading to a lower temperature being recorded by the functionalized thermocouple. With this method, it was possible to measure various compounds, ranging from small targets such as the antibiotic vancomycin to larger biomarkers such as troponin, in the low nanomolar regime in buffered solutions. The sensitivity was significantly enhanced by using standard EDC coupling to covalently attach the nanoparticles to the surface, allowing to control the surface architecture. Finally, the design of the current flow cell was adjusted to incorporate four thermocouples, demonstrating the first multiplex format of this sensor platform. In this presentation, a case study on the detection of cardiac biomarkers, including troponin, will be discussed.
Add to Calendar ▼2019-06-18 00:00:002019-06-19 00:00:00Europe/LondonPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019Point-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-06-19 08:30:002019-06-19 09:30:00Europe/LondonSmart Thermometers: Screening for Biomarkers Using Molecularly Imprinted Polymers (MIPs) Combined with Thermal DetectionPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
