Mikael Kubista's Biography

Mikael Kubista, Professor/Founder, TATAA Biocenter AB

Dr Kubista is founder and CEO of the TATAA Biocenters (www.tataa.com) and he is also head of the department of gene expression at the institute of Biotechnology of the Czech Academy of Sciences. He was one of the pioneers contributing to the development of quantitative real-time PCR (qPCR) and introduced qPCR for single cell expression profiling. He led the development of reagents for high throughput expression profiling at his team develop qPCR tomography for intracellular expression profiling. Most recently Kubista co-developed ValidPrime.

Roundtable Discussion

Monday, 10 March 2014 at 17:30

Add to Calendar ▼2014-03-10 16:45:002014-03-10 17:45:00Europe/LondonTaking Single Cell Expression Profiling to New DimensionsSingle Cell Analysis Europe 2014 in Berlin, GermanyBerlin, GermanySELECTBIOenquiries@selectbiosciences.com

• What contributes to single cell heterogeneity?

• (Why) are mRNA and protein expression bursts at different time scales?

• How do we define cell type? Can single cell profiling help?

• Single cell analysis in clinical practice? What´s needed?

Taking Single Cell Expression Profiling to New Dimensions

Monday, 10 March 2014 at 16:45

In the first part of my talk I will describe high throughput single cell profiling of astrocytes from mouse brains performed over time after induced trauma. The profiling reveals how the brain responds to the injury, activating the astrocytes to attempt repair. Expression of many genes, measured in large number of cells, over time is a so called multiway study, from which most valuable information about the molecular processes involved and expression pathways active can be extracted with powerful multivariate tools such as dynamic PCA available in the GenEx software. In the second part of my talk I will present single cell multianalyte profiling, showing how DNA, mRNA, microRNA, lncRNA, and protein can be measured in the same cell.

Add to Calendar ▼2014-03-10 00:00:002014-03-11 00:00:00Europe/LondonSingle Cell Analysis Europe 2014Single Cell Analysis Europe 2014 in Berlin, GermanyBerlin, GermanySELECTBIOenquiries@selectbiosciences.com

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