Rong Fan,
Harold Hodgkinson Professor of Biomedical Engineering,
Yale University
Dr. Rong Fan is the Harold Hodgkinson Professor of Biomedical Engineering at Yale University and Professor of Pathology at Yale School of Medicine. He received a Ph.D. in Chemistry from the University of California at Berkeley and completed the postdoctoral training at California Institute of Technology before joining the faculty at Yale University in 2010. His current interest is focused on developing microtechnologies for single-cell and spatial omics profiling to interrogate functional cellular heterogeneity and inter-cellular signaling network in human health and disease (e.g., cancer and autoimmunity). He co-founded IsoPlexis, Singleron Biotechnologies, and AtlasXomics. He served on the Scientific Advisory Board of Bio-Techne. He is the recipient of a number of awards including the National Cancer Institute’s Howard Temin Career Transition Award, the NSF CAREER Award, and the Packard Fellowship for Science and Engineering. He has been elected to the American Institute for Medical and Biological Engineering (AIMBE), the Connecticut Academy of Science and Engineering (CASE), and the National Academy of Inventors (NAI).
Microvasculature-on-a-chip for Tissue Engineering and Precision Medicine
Thursday, 17 March 2016 at 15:00
Add to Calendar ▼2016-03-17 15:00:002016-03-17 16:00:00Europe/LondonMicrovasculature-on-a-chip for Tissue Engineering and Precision MedicineSELECTBIOenquiries@selectbiosciences.com
One of the major challenges in tissue engineering for transplantation and regenerative medicine is revascularization. Due to the complexity of angiogenesis and vasculogenesis mediated by a host of cellular and soluble mediators, it remains a daunting challenge to recapitulate the perivascular microenvironment in vitro for effective neotissue vascularization prior to transplantation. Stromal cells, such as fibroblasts and pericytes, provide not only mechanical support but also paracrine signals to regulate vascular morphogenesis and function. We are working to develop integrative microsystems that combine various stromal cell components and soluble signals derived therefrom to engineer high quality microvasculature network in vitro with the ultimate goal to achieve revascularization of large-sized neotissues and thus improve the performance post transplantation. First, we are harnessing the paracrine signals from phenotypically modified stromal cells (e.g., fibroblasts) to create endothelialized microvessel network in native extracellular matrix (e.g., collagen, fibrin, etc) hydrogels. Second, we are applying this platform to revascularization of mouse pancreatic islets in vitro, which can accelerate functional anastomosis with host tissue after implantation. The vascularized islets are characterized for glucose sensing and insulin production in response to glucose. Third, leveraging the success of in vitro tissue revascularization to build a brain tumor perivascular niche (PVN)-on-a-chip model to investigate the dynamics of glioma stem/progenitor cells in PVN and their resistance or response to treatment. All together, these are to address a critical need in tissue engineering and open new opportunities for in vitro modeling of tumor microenvironment for precision medicine.
Add to Calendar ▼2016-03-17 00:00:002016-03-18 00:00:00Europe/LondonTissue EngineeringSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2016-03-17 15:00:002016-03-17 16:00:00Europe/LondonMicrovasculature-on-a-chip for Tissue Engineering and Precision MedicineSELECTBIOenquiries@selectbiosciences.com
