Dolores Di Vizio's Biography

Dolores Di Vizio, Professor, Cedars Sinai Medical Center

Dr. Dolores Di Vizio is a pathologist and a molecular and cell biologist trained at Albert Einstein College of Medicine, and Harvard Medical School. Dr. Di Vizio holds an academic appointment as associate professor at Cedars-Sinai Medical Center, and at the University of California, Los Angeles. She is an Executive Chair of the International Society of Extracellular Vesicles (ISEV). Her group studies the molecular mechanisms of progression to advanced disease in human tumors, with a particular emphasis on large oncosomes, extracellular vesicles (EVs) shed into the extracellular space from fast migrating and metastatic amoeboid cancer cells. Her lab is currently profiling the large oncosomes and other EV populations by NGS and proteomics for functional and molecular characterization.

Heterogeneity of Cancer-Derived Extracellular Vesicles

Tuesday, 22 March 2016 at 13:30

Add to Calendar ▼2016-03-22 13:30:002016-03-22 14:30:00Europe/LondonHeterogeneity of Cancer-Derived Extracellular VesiclesSELECTBIOenquiries@selectbiosciences.com

Cancer cells release oncogenic cargo in bioactive extracellular vesicles (EVs) that can alter the tumor microenvironment and elicit behavioral responses in target cells. This discovery points to a role in tumor evolution for a conserved and finely regulated biological process that allows intercellular transfer of bioactive proteins, nucleic acids and lipids in the form of pre-assembled plasma membrane structures. In the last few years, it has emerged that every cell can release different types of EVs, with selective cargo and function. Studies on exosomes, for example, have demonstrated that diverse types of exosomes can be released by tumor cells. Several new methodologies are being interrogated to differentiate between exosomes with different cargo/functions. Different populations of exosomes as well as of larger EV types including the large oncosomes could provide clinically relevant information.

Add to Calendar ▼2016-03-21 00:00:002016-03-22 00:00:00Europe/LondonExosomes and Microvesicles: Research, Biomarker Cargo and Therapeutic PotentialSELECTBIOenquiries@selectbiosciences.com

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