Casey Maguire,
Assistant Professor of Neurology,
Harvard Medical School
Casey Maguire earned his PhD from the University of Rochester School of Medicine and Dentistry in 2006. In both his pre and postdoctoral research he has focused on the development of viral and nonviral gene delivery systems to improve the efficacy of gene therapy platforms.
Evaluation of a Hybrid Exosome/Virus Vector System for Gene Transfer and Therapy in Preclinical Models of Human Disease
Tuesday, 22 March 2016 at 08:30
Add to Calendar ▼2016-03-22 08:30:002016-03-22 09:30:00Europe/LondonEvaluation of a Hybrid Exosome/Virus Vector System for Gene Transfer and Therapy in Preclinical Models of Human DiseaseSELECTBIOenquiries@selectbiosciences.com
Adeno-associated virus (AAV) vectors have shown remarkable efficiency in a number of preclinical models of disease in several organs including the eye, brain, muscle, heart, and liver. A major limitation to long term transduction, especially via the systemic route, is pre-existing immunity (humoral and cell-mediated) as well as the high vector load required to achieve sufficient levels of gene expression in the desired organ. Natural nanoparticles released from all cells, called exosomes, may have utility in creating better AAV vectors for human gene therapy. We have previously shown that harvesting AAV vectors from the media of 293T producer cells contains AAV vectors associated with exosomes (called exo-AAV). We have gone on to demonstrate that 293T-derived exo-AAV can evade neutralizing anti-AAV antibodies and greatly increase transduction in mice. Here we will report on our findings of the gene transfer capabilities of exo-AAV to several organs of interest in human disease including the brain, liver, muscle, eye, and cochlea.
Add to Calendar ▼2016-03-21 00:00:002016-03-22 00:00:00Europe/LondonExosomes and Microvesicles: Research, Biomarker Cargo and Therapeutic PotentialSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2016-03-22 08:30:002016-03-22 09:30:00Europe/LondonEvaluation of a Hybrid Exosome/Virus Vector System for Gene Transfer and Therapy in Preclinical Models of Human DiseaseSELECTBIOenquiries@selectbiosciences.com
