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Characterization of plasma Extracellular Vesicles with Human Age

Tuesday, 22 March 2016 at 11:00

Add to Calendar ▼2016-03-22 11:00:002016-03-22 12:00:00Europe/LondonCharacterization of plasma Extracellular Vesicles with Human AgeSELECTBIOenquiries@selectbiosciences.com

Extracellular vesicles (EVs; also known as exosomes) are released from most cells into the extracellular environment and circulation. Thus, EVs play a potentially important role in intercellular communication between different cell types throughout the body.  Research has primarily focused on characterizing the proteins, lipids, and RNAs contained in EVs from various disease states, including cancer. As many of the pathological conditions where EVs have been implicated are age-related, it is likely that there changes in EVs with age in humans.  However, little is known about whether there are age-dependent changes in EV concentration (size and number), composition or function with human age.  We used a longitudinal cohort of 75 individuals from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study to characterized EV concentration and surface proteins. We found a significant reduction in their concentration with age. Establishing a profile of EVs with human age will further aid in the development of diagnostics and therapies using EV-designed technologies for age-related diseases.