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SELECTBIO Conferences Extracellular Vesicles (EVs): Technologies & Biological Investigations
Conferences  \  Extracellular Vesicles (EVs): Technologies & Biological Investigations  \  Agenda  \  Christopher Shields
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Christopher Shields's Biography


Christopher Shields, Research Assistant, Thomas Jefferson University

Christopher Shields, in the Languino laboratory at the Sydney Kimmel Cancer Center at Thomas Jefferson University, has an undergraduate degree in physics. Christopher is studying the mechanisms mediated by extracellular vesicles that promote progression from prostate cancer to castrate-resistant prostate cancer to neuroendocrine prostate cancer, and whether the progression can be inhibited. Christopher is working alongside Dr. Quaglia, a post-doc fellow, focusing on alphaVbeta3 integrin and NgR2, identifying potential biomarkers and therapeutic targets in vivo and in vitro for the highly aggressive neuroendocrine prostate cancer.

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Small Extracellular Vesicles Modulated by the alphaVbeta3 Integrin Reprogram Recipient Prostate Cancer Cells Towards an Aggressive Neuroendocrine Phenotype

Wednesday, 15 December 2021 at 15:30

Add to Calendar ▼2021-12-15 15:30:002021-12-15 16:30:00Europe/LondonSmall Extracellular Vesicles Modulated by the alphaVbeta3 Integrin Reprogram Recipient Prostate Cancer Cells Towards an Aggressive Neuroendocrine PhenotypeExtracellular Vesicles (EVs): Technologies and Biological Investigations in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Neuroendocrine prostate cancer (NEPrCa) is a highly aggressive subtype of prostate cancer (PrCa) that can arise as a result of androgen deprivation therapies or it may arise de novo. The alphaVbeta3 integrin is shown to be upregulated in NEPrCa primary tumor samples and treatment of PrCa cells with small extracellular vesicles (sEVs) containing alphaVbeta3 has been observed to play role in tumor formation, proliferation, and survival in vitro and in vivo. Moreover, upon treatment with alphaVbeta3 vesicles, neuroendocrine differentiation is observed, implying a functional role of sEV integrins in reprogramming of recipient cells.

Add to Calendar ▼2021-12-13 00:00:002021-12-15 00:00:00Europe/LondonExtracellular Vesicles (EVs): Technologies and Biological InvestigationsExtracellular Vesicles (EVs): Technologies and Biological Investigations in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com


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