Paul Bohn,
Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry,
University of Notre Dame
Paul W. Bohn received the B.S. from the University of Notre Dame in 1977 and the Ph.D. from the University of Wisconsin-Madison in 1981, both in Chemistry. After two years at Bell Laboratories, he joined the faculty at the University of Illinois at Urbana-Champaign (UIUC). In 2006, he moved to the University of Notre Dame where he is currently the Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering, Professor of Chemistry and Biochemistry, and Director of the Institute for Precision Health. He served as Editor for the Americas for the RSC journal Analyst 2007-09 and as Chair of the Editorial Board 2010-14. Prof. Bohn is currently co-editor of Annual Review of Analytical Chemistry. His research interests include: (a) integrated nanofluidic and microfluidic chemical measurement strategies for personal monitoring, (b) chemical and biochemical sensing in mass-limited samples, (c) biochemical imaging, and (d) molecular approaches to nanotechnology, areas in which he has over 290 publications and 10 patents.
Lab-on-a-Chip Studies of Bacterial Communities -- Spatiotemporal Characterization of Chemical Signaling and Virulence Agents
Thursday, 10 September 2020 at 16:15
Add to Calendar ▼2020-09-10 16:15:002020-09-10 17:15:00Europe/LondonLab-on-a-Chip Studies of Bacterial Communities -- Spatiotemporal Characterization of Chemical Signaling and Virulence AgentsMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Despite the fact that most microorganisms occupy 2- and 3-dimensional space in heterogeneous ways and do not exist in monoculture, much of our current knowledge about the relation of bacteria to disease processes is derived from homogenizing, then analyzing, the chemical content of monocultures - an approach that yields no information about the 3D production and dispersal of secreted factors. To address this need, we are developing lab-on-a-chip (LOC) methods involving nanofluidics and spectroelectrochemistry to characterize the spatiotemporal evolution of secreted chemical factors used by bacteria to organize their community structures. LOC approaches are ideal for these studies, because they facilitate: (a) characterization of different mobility conditions, e.g. swarm, twitch, biofilm, etc.; (b) development and subsequent analysis of co-cultures of antagonistic bacterial species; (c) analysis of microbial communities in the presence of antibiotics; and (d) protein (mucin) templating of regulated surface communities. We have characterized the phenotypic responses and spatial variability of alkyl quinolones, including the Pseudomonas quinolone signal (PQS) and members of the alkyl hydroxyquinoline (AQNO) subclass, in P. aeruginosa swarming communities as well as the electrochemical and spectroscopic behavior of the phenazine class of virulence factors used by this species.
Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2020-09-10 16:15:002020-09-10 17:15:00Europe/LondonLab-on-a-Chip Studies of Bacterial Communities -- Spatiotemporal Characterization of Chemical Signaling and Virulence AgentsMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
