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SELECTBIO Conferences Microfluidics & Flow Chemistry Europe 2020

Microfluidics & Flow Chemistry Europe 2020 Agenda


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Thursday, 25 June 2020

00:00

Title to be Confirmed.
Shawn Collins, Full Professor, Université de Montréal, Canada

00:00

Francesca ParadisiKeynote Presentation

Bridging the Gap Between Academia and Industry by Developing Robust and Scalable Biocatalytic Process in Continuous Production
Francesca Paradisi, Professor of Pharmaceutical and Bioorganic Chemistry, University of Bern, Switzerland

To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate the reliability of enzyme-based methodologies directly applied to the production of high value products. Here the merging of flow technology with biocatalysis will be presented, showcasing the rapid evolution we achieved in our research group moving from analytical to preparative scale for the synthesis of valuable chemicals, while tackling a range of limitations such as substrate insolubility and cofactor recycling.

00:00

Flow Technology for the Development of Synthetic Methodologies Based on Highly Reactive Intermediates
Renzo Luisi, Professor of Organic Chemistry, University of Bari, Italy

In the field of organic synthesis, the advent of flow chemistry and microreactor technology represented a tremendous novelty in the way of thinking and performing chemical reactions. These enabling technologies opened the doors to chemical transformations considered impossible if run under traditional batch processing. In this presentation, the impact of flow chemistry in the use of highly reactive organometallic reagents, and in particular organolithiums will be reported. Examples of isomerizations, carboxylations, and homologation reactions conducted under flow conditions will be discussed.

00:00

Dong Pyo KimKeynote Presentation

Title to be Confirmed.
Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH), Korea South

00:00

Title to be Confirmed.
Nick Thomson, Senior Director, Chemical Research and Development , Pfizer, Inc., United States of America

00:00

Paul WattsKeynote Presentation

Continuous Flow Manufacturing: Africa’s Possibility of Developing API Manufacturing
Paul Watts, Research Chair in Microfluidic Bio/Chemical Processing, Nelson Mandela University, South Africa

While Africa has a variety of companies that formulate medicines it does not have any form of pharmaceutical industry that manufactures the active pharmaceutical ingredients (APIs) with the consequence that these need to be imported from overseas. This results in increased drug costs making medications unaffordable to most patients in Africa as they fall in the low-middle income bracket. To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. We are developing cost effective and efficient continuous flow synthetic processes towards a variety of drugs to demonstrate that they can be manufactured at lower cost in Africa.

00:00

Continuous Flow Organic Chemistry at the Interface of Current Societal Challenges
Jean-Christophe Monbaliu, Associate Professor, Center for Integrated Technology and Organic Synthesis, University of Liège, Belgium

Current active research areas in the lab include methodology for continuous flow organic synthesis with an impact on current important societal challenges. This lecture illustrates our most recent work within three main specific research areas: (a) the development of innovative, flexible and low environmental footprint synthetic strategies for the preparation of high value-added chemicals (small molecule APIs and large biomacromolecules), (b) the upgrading of bio-based platform molecules and (c) the neutralization of chemical warfare agents.

00:00

Amanda EvansKeynote Presentation

Title to be Confirmed.
Amanda Evans, Scientist, Los Alamos National Laboratory, United States of America

00:00

Peter SeebergerKeynote Presentation

Title to be Confirmed.
Peter Seeberger, Managing Director, Max Planck Institute of Colloids and Interfaces, Professor Freie Universität Berlin, Germany

00:00

Stereoselective Catalytic Reactions in (micro)Mesoreactors
Maurizio Benaglia, Full Professor of Organic Chemistry, Dipartimento di Chimica, Università degli Studi di Milano, Italy

(Organo)catalytic, stereoselective reactions involving nitro derivatives in batch and in (micro)-mesoreactors will be presented, and compared with stereoselective catalytic in-flow reactions in 3D-printed reactors. The fabrication of ad hoc designed reactors and other devices, to perform different reactions becomes now feasible and gives new impulse to the use of enabling technologies in the synthesis of complex molecules. The metal-free reduction of nitro compounds to amines mediated by trichlorosilane will be also discussed, comparing the in-batch procedure and  the continuous flow process performed in mesoreactors.

00:00

Heidrun Gruber-WölflerKeynote Presentation

Title to be Confirmed.
Heidrun Gruber-Wölfler, Associate Professor, Graz University of Technology, Austria

00:00

Title to be Confirmed.
Shinichiro Fuse, Professor, Nagoya University, Japan

00:00

Interfacing Advanced Ion Mobility Spectrometry to Microfluidic Technologies
Maarten Honing, Professor, Maastricht University, M4I Institute Maastricht MultiModal Molecular Imaging, Netherlands

00:00

Ian BaxendaleKeynote Presentation

Title to be Confirmed.
Ian Baxendale, Professor, Durham University, United Kingdom

00:00

C. Oliver KappeKeynote Presentation

Title to be Confirmed.
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria

00:00

Paul BohnKeynote Presentation

Lab-on-a-Chip Studies of Bacterial Communities -- Spatiotemporal Characterization of Chemical Signaling and Virulence Agents
Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry, University of Notre Dame, United States of America

Despite the fact that most microorganisms occupy 2- and 3-dimensional space in heterogeneous ways and do not exist in monoculture, much of our current knowledge about the relation of bacteria to disease processes is derived from homogenizing, then analyzing, the chemical content of monocultures - an approach that yields no information about the 3D production and dispersal of secreted factors.  To address this need, we are developing lab-on-a-chip (LOC) methods involving nanofluidics and spectroelectrochemistry to characterize the spatiotemporal evolution of secreted chemical factors used by bacteria to organize their community structures. LOC approaches are ideal for these studies, because they facilitate: (a) characterization of different mobility conditions, e.g. swarm, twitch, biofilm, etc.; (b) development and subsequent analysis of co-cultures of antagonistic bacterial species; (c) analysis of microbial communities in the presence of antibiotics; and (d) protein (mucin) templating of regulated surface communities. We have characterized the phenotypic responses and spatial variability of alkyl quinolones, including the Pseudomonas quinolone signal (PQS) and members of the alkyl hydroxyquinoline (AQNO) subclass, in P. aeruginosa swarming communities as well as the electrochemical and spectroscopic behavior of the phenazine class of virulence factors used by this species.

00:00

Title to be Confirmed.
Tanja Junkers, Professor, School of Chemistry, Polymer Reaction Design group, Monash University, Australia

00:00

Development of Flow-based Syntheses of Pharmaceuticals
Darren Riley , Senior Lecturer , University of Pretoria , South Africa

The presentation will focus on the development of flow-based synthetic routes to several pharmaceuticals and will include aspects of batch-flow hybridization and reaction engineering. Insight will also be given pertaining to the use of flow technology as a disruptive leap-frogging technology for the localization of pharmaceutical manufacturing in developing countries like South Africa.

00:00

Digital Flow Chemistry for Natural Product Synthesis
François-Xavier Felpin, Professor, University of Nantes, France

In this presentation we will present a reconfigurable flow platform for either reagent screening and self-optimization.

00:00

Multistep Synthesis of API Precursors in Continuous Flow Involving Heterogeneous Palladium Catalysis
Katharina Hiebler, Project Assistant / Researcher, TU Graz, Austria

Late-stage precursors of the two active pharmaceutical ingredients valsartan and sacubitril have successfully been synthesized in continuous flow using a multistep setup. The key step of the reaction cascades, Suzuki-Miyaura cross coupling, is facilitated by heterogeneous palladium catalysis.


Agenda is not currently available
Add to Calendar ▼2020-06-25 00:00:002020-06-26 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com