Dong Pyo Kim,
Yonsan Chaired Professor,
Pohang University of Science And Technology (POSTECH)
Professor Dong-Pyo Kim has extensive general experience and more than 25 year track record in synthetic and physical organic chemistry, process intensification using microreactors and flow chemistry/microreaction technology, communicated in ~300 scientific publications (h-index 52, citation 8,133). For the past decade the focus of his research has been directed towards flow chemistry using microreactor, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and sustainable manufacturing, employing a number of different enabling and process intensification technology.
Microfluidic Approaches for Scale-up Chemical Production via Numbering-up & Ultrafast Chemistry
Thursday, 10 September 2020 at 14:00
Add to Calendar ▼2020-09-10 14:00:002020-09-10 15:00:00Europe/LondonMicrofluidic Approaches for Scale-up Chemical Production via Numbering-up and Ultrafast ChemistryMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Continuous-flow technology is emerging for efficient, sustainable and safe synthesis of drug and the precursors. In here, scale-up chemical production are efficiently demonstrated by adopting both approaches of numbering-up microreactors and ultrafast chemical synthesis at high flow rates. Firstly, various numbering-up microreactor systems were designed and manufactured with stainless steel metal or polymer films. The compact and robust reactors demonstrated scale-up production of several drug compounds via azide-alkyne reaction, fast synthesis of organophosphates. Moreover, photocatalysis in a multi-capillary assembly system, 3D printed reactors were used to improve the synthetic productivity. Alternatively, ultrafast synthetic approaches were performed by taming the lithiated flash chemistry in unique microreactors at high flow rates, which envisions facile scale-up production of drugs. Unique design of a chip microreactor enabled submillisecond mixing time even at low temperatures, which was used for outpacing rapid intramolecular rearrangements such as anionic Fries rearrangement to attain high chemoselectivity. And 3D-printed stainless steel microreactor with circular shape of cross-sectional fluidic channel enhanced the intramolecular control for higher yield of the un-rearranged product. Further, a 16 stacked reactor system of circular channel structure with superior mixing efficiency was alternatively devised to synthesize commercial Letrozole drug by newly developed 3 steps route, including ~10 milliseconds of flash chemistry.
Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2020-09-10 14:00:002020-09-10 15:00:00Europe/LondonMicrofluidic Approaches for Scale-up Chemical Production via Numbering-up and Ultrafast ChemistryMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
