Séverine Le Gac,
Professor, Applied Microfluidics for Bioengineering Research, MESA+ Institute for Nanotechnology,
University of Twente
Séverine Le Gac is Professor at the University of Twente, The Netherlands, where she leads a team called “Applied Microfluidics for BioEngineering Research – AMBER”. Séverine Le Gac received her Engineer degree in chemistry (specialization biology) from the ESPCI (Paris, France) in 2000 and her PhD cum laude in 2004 in life sciences from the University of Lille (France). She has about 20 years experience in the field of microfluidics focusing on bioanalytical, biological and medical applications. Her research interests focus on the use of microfluidic devices and organ-on-chip models for biological and medical applications, including experimentation on single cells, analysis of extracellular vesicles, cancer research, assisted reproductive technologies, and the incorporation of biomechanical cues in organ-on-chip models. Prof. Le Gac is Associate Editor of the Lab on a chip journal (RSC), co-editor-in-chief of the Organs-on-a-chip journal (Elsevier) and part of the advisory board of the Journal of Micromechanics and Microengineering (IOP Publisher). Since 2018, she has also been Member of the Director Board of the CBMS Society (Chemical and Biological Microsystem Society; https://cbmsociety.org/), of which she is currently the vice-president.
Organ-on-a-Chip Models for Cancer Research
Tuesday, 29 June 2021 at 09:30
Add to Calendar ▼2021-06-29 09:30:002021-06-29 10:30:00Europe/LondonOrgan-on-a-Chip Models for Cancer Research3D-Culture, Organoids and Organ-on-a-Chip Europe 2021 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Organ-on-a-chip (OoC) technology has become a game-changer by providing advanced in vitro models of human tissues and organs, allowing thereby conducting a variety of experimentation and assays, ranging from drug testing, toxicity screening, tissue engineering, to disease modeling to, e.g., elucidate mechanisms at play in disease onset and progression. Organ-on-a-chip devices are hybrid models combining cells and microfabricated structures in a microfluidic format, aiming altogether to mimic functional and/or structural features of an organ. OoCs exhibit a number of advantages compared to conventional in vitro and in vivo models: an in vivo–like and tunable microenvironment, dynamic culture, possibility to incorporate a variety of (bio)chemical and (bio)physical cues, with spatial and temporal control thereon, suitability to prepare patient-specific (disease) model, amenability to parallelized and automated studies, and compatibility with routine imaging and molecular assay. As such, OoC is currently acknowledged as a promising technology to reduce and replace experimentation on animals, which are poor mimics of human diseases and physiology. In my presentation, I will discuss recent work from our group in the field of cancer research: to develop tumor models including different features found in the tumor microenvironment in vivo; to evaluate the penetration of nanomedicines in multi-cellular tumor spheroids, in the presence of a flow or under the assistance of microbubbles and ultrasound activation; to assess the impact of (bio)mechanical cues on a tumor model; and to study cancer metastasis using a multi-organ-on-a-chip approach.
Add to Calendar ▼2021-06-28 00:00:002021-06-30 00:00:00Europe/London3D-Culture, Organoids and Organ-on-a-Chip Europe 20213D-Culture, Organoids and Organ-on-a-Chip Europe 2021 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2021-06-29 09:30:002021-06-29 10:30:00Europe/LondonOrgan-on-a-Chip Models for Cancer Research3D-Culture, Organoids and Organ-on-a-Chip Europe 2021 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
