Charles Wang,
Director & Professor,
Loma Linda University
Dr. Wang, MD, PhD, MPH, is Director of the Center for Genomics and a Professor in the School of Medicine, Loma Linda University (LLU). He had held the positions as Director of the Functional Genomics Core at City of Hope National Medical Center, Associate Professor of Medicine at the David Geffen School of Medicine at UCLA and Director of the Clinical Transcriptional Genomics Core at Cedars-Sinai Medical Center before joining LLU. Dr. Wang is a recipient of several awards, including the AACR-Bristol-Myers Squibb Young Investigator Award of the American Association for Cancer Research and the first place graduate award for Research Excellence of Society of Toxicology. Dr. Wang serves as Editorial Board Members for World Journal of Stem Cells, the Frontiers, and the Single Cell Genomics & Proteomics, the Journal of Clinical and Experimental Genetics, the Aperito Journal of Computer Science and Biology, and Associate Editor for the RNA & Diseases. Dr. Wang is an expert on genomics and transcriptomics, with many high visibility peer-reviewed papers published in the high profile journals such as Nature Biotechnology, Nature Communications and PNAS. He was one of the project leaders for the FDA-led international working group/consortium on MicroArray Quality Control (MAQC) and Sequencing Quality Control (SEQC) projects.
Single-cell Transcriptome and Epigenomic Reprogramming of Adult Cardiomyocyte-dedifferentiated Cardiac Progenitor Cells
Wednesday, 28 September 2016 at 11:45
Add to Calendar ▼2016-09-28 11:45:002016-09-28 12:45:00Europe/LondonSingle-cell Transcriptome and Epigenomic Reprogramming of Adult Cardiomyocyte-dedifferentiated Cardiac Progenitor CellsNGS, SCA, SMA and Mass Spec: Research to Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
It has been believed that mammalian adult cardiomyocytes (ACMs) are terminally differentiated and are unable to proliferate. Recently, using a bi-transgenic mouse model and an in vitro culture system, we demonstrated that adult mouse cardiomyoctyes were able to dedifferentiate into cardiac progenitor-like cells (CPCs). In addition, implantation of CPCs into infarcted mouse myocardium improves cardiac function with augmented left ventricular ejection fraction. However, little is known about the molecular basis of their intrinsic cellular plasticity. Here we integrate whole-genome single-cell transcriptome and comprehensive high-throughput arrays for relative methylation (CHARM)-based DNA methylation analyses to unravel the molecular mechanisms underlying the focused, spontaneous dedifferentiation of mouse ACMs which gave rise to CPCs.
Add to Calendar ▼2016-09-26 00:00:002016-09-28 00:00:00Europe/LondonNGS, SCA, SMA and Mass Spec: Research to Diagnostics 2016NGS, SCA, SMA and Mass Spec: Research to Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2016-09-28 11:45:002016-09-28 12:45:00Europe/LondonSingle-cell Transcriptome and Epigenomic Reprogramming of Adult Cardiomyocyte-dedifferentiated Cardiac Progenitor CellsNGS, SCA, SMA and Mass Spec: Research to Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
