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SELECTBIO Conferences Exosomes and Microvesicles

Xandra Breakefield's Biography

Xandra Breakefield, Professor, Mass General Hospital (MGH)/Harvard Medical School

Xandra Breakefield, Ph.D. is a basic scientist with a strong background in molecular genetics and neuroscience. She focuses her research efforts on: gene therapy for neurologic diseases; and elucidation of the role of extracellular vesicles (EVs) released from cancer cells in tumor progression. She led early studies demonstrating mutant RNA in serum EVs from glioblastoma patients as biomarkers. She did her undergraduate work at Wilson College and her graduate work in Microbial Genetics at Georgetown University. She was a Postdoctoral Fellow with Nobel Prize winner, Dr. Marshall Nirenberg at the NIH. She is currently Professor of Neurology in the Neuroscience Program at Harvard Medical School and Geneticist in the Neurology and Radiology Services at Massachusetts General Hospital.

Professor Breakefield has received a number of awards for her work, including a McKnight Foundation Neuroscience Development Award, two Javits Neuroscience Investigator Awards, the Society for Neuroscience Mika Salpeter Lifetime Achievement Award, and the Harvard Medical School William Silen Lifetime Achievement Mentoring Award. She is a member of the National Academy of Arts and Sciences and past president of the American Society of Gene and Cell Therapy.

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Extracellular RNA in Biofluids as Biomarkers of Disease

Monday, 23 March 2015 at 11:30

Add to Calendar ▼2015-03-23 11:30:002015-03-23 12:30:00Europe/LondonExtracellular RNA in Biofluids as Biomarkers of

Most cells in the body release extracellular RNA (exRNA) within vesicles or in association with ribonucleoprotein/lipoprotein particles.  This overview talk will consider the types of RNA released, the biofluids analyzed, and modes of evaluation of the quantity and sequence of exRNAs as a index of different disease states. Examples will be provided for analysis of exRNA from serum/plasma, urine and cerebral spinal fluid of cancer patients with a focus on discovery of novel non-coding RNAs and quantitation of rare, mutant RNAs.

Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonExosomes and