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New Tools and Recent Applications in Flow Chemistry at MSD

Friday, 15 November 2019 at 10:00

Add to Calendar ▼2019-11-15 10:00:002019-11-15 11:00:00Europe/LondonNew Tools and Recent Applications in Flow Chemistry at MSDFlow Chemistry Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com

The manufacturers of active pharmaceutical ingredients (APIs) and their intermediates have recently rediscovered flow chemistry and continuous processing. This renewed interest in these technologies has arisen from the anticipated benefit in supply chain economics and regulatory pressure in addition to the obvious opportunity for improved control including heat and mass transfer, process safety, access to high pressure and high temperature conditions, and use of supported catalysts and biocatalysts.

To take advantage of these benefits it is often necessary to develop new tools and platforms, including methods for characterizing fast mixing reactions or new reactors for scaling up photochemical reactions. This talk will describe the development of some of these tools and the subsequent application of these tools to pharmaceutical manufacturing processes.

John Naber, Director, Flow Chemistry and Lab Automation, Process Research & Development, Merck & Co

John leads the Flow Chemistry and Lab Automation teams within Enabling Technologies as part of Process Research & Development at MSD. The New Jersey based flow team works closely with the larger process organization to implement flow chemistry processes during late stage and commercial route development.

John began his industrial career at i2Chem a Cambridge (MA) based CRO that specialized in flow chemistry process development before moving to MSD in 2012. John received his PhD from the Massachusetts Institute of Technology in 2010 where he completed his research under the direction of Stephen L. Buchwald. During his time at MIT he was introduced to flow chemistry through the MIT-Novartis Center for Continuous Manufacturing. He holds a BSc in Chemistry from the University of Victoria in Canada.