Clinical Applications of Mass Spectrometry Agenda

Registration

Creating a Clinical Diagnostic Test from Discovery through Launch with Mass Spectrometry
Daniel Chelsky, Chief Scientific Officer, Caprion Proteomics Inc, Canada

Hundreds of candidate protein biomarkers can be rapidly triaged, using MRM mass spectrometry, without the use of antibodies.  A case study will be presented that led to a commercialized test for benign vs. malignant pulmonary nodules.

Coffee and Networking in Exhibition Hall

Quantitative Mass Spectrometry of Peptides and Proteins, A New Era in Clinical Biomarker Detection
Sylvain Lehmann, Professor, University Hospital Montpellier, France

The utility of mass spectrometry for peptides and proteins in clinical chemistry will be discussed, using amyloid peptides, tau protein and apolipoprotein E as examples.

Biomarker Discovery in Men’s Cancer
Rainer Cramer, Professor, University of Reading :(, United Kingdom

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Breast Cancer Biomarkers From Discovery to Early Validation by Proteomics
Janne Lehtio, Associate Professor, Karolinska Institutet, Sweden

Proteome analysis revealed retinoic acid receptor as potential prognostic and predictive marker in endocrine resistant breast cancer. Further, in-depth quantitative proteome and proteogenomics analysis of breast cancer sub-types will be presented.

Intraoperative Identification of Tissues by Rapid Evaporative Ionization Mass Spectrometry
Zoltan Takats, Professor, Imperial College London, United Kingdom

Coffee and Networking in Exhibition Hall

Steroid Homeostasis and Clinical Mass Spectrometry; Moving Beyond Concentration
Ruth Andrew, Reader, Edinburgh University, United Kingdom

Conventional MS methods for quantitation of concentrations of steroids will be contrasted with measurement of dynamic turnover of steroids using stable isotope tracers and also steroids within intact tissue using MS imaging.

Advantage of Steroid Analysis by LC-MS/MS in Laboratory Medicine
Uta Ceglarek, Senior Scientist, University Hospital Leipzig, Germany

Application of LC-MS/MS for steroid analysis combining multi-parametric analysis, high sensitivity and specificity as well simple sample pretreatment, and low running costs and its perspective role in the standardization of steroid measurements in clinical routine application will be discussed.

Drinks Reception

End of Day One

Applications of LC-MS/MS to Therapeutic Drug Monitoring: Recent Developments and Future Directions for a Personalized Medicine
Laurent Decosterd, Associate Professor, Universite de Lausanne, Switzerland

The presentation will give various clinical applications of the LC tandem MS technology for the multiplex bioanalysis of several classes of drugs within the frame of Therapeutic Drug Monitoring; opening the way of Personalized Medicine whereby drug dosage is individualized in each patient for maximizing the therapeutic benefit and tolerability of drugs.

Therapeutic Drug Monitoring of Linezolid
Michael Vogeser, Professor, University of Munich, Germany

The presentation will address the clinical background and the technological realisation of therapeutic drug monitoring of linezolid in critically ill patients.

Coffee and Networking in Exhibition Hall

LC-High Resolution-MS in Clinical Labs: A Step Forward for TDM and Metabotyping
Bertrand Rochat, Head Quantitative Mass Spectrometry Facility , Centre Hospitalier Universitaire Vaudois, Switzerland

Using high-resolution (HR) full-scan acquisition, actual HR-MS can perform simultaneously qualitative and quantitative analyses that are compatible with routine environment. Actual HR-MS shows comparable selectivity, sensitivity, level accuracy and analytical throughput than triple-quadrupole-MS. Research/routine and quantitative/qualitative analyses using LC-HR-MS will be presented for drug and peptide determinations in patients’ plasma.

Quantification of Volatile Metabolites in Exhaled Breath and Biological Fluids by SIFT-MS in Support of Clinical Diagnosis
David Smith, Professor, Keele University, United Kingdom

The novel SIFT-MS analytical method and its application to the detection and quantification in exhaled breath of volatile biomarkers of diseases such as cystic fibrosis, bowel disease, diabetes and chronic kidney disease, in support of clinical diagnosis, are described.

Lunch & Networking in Exhibition Hall

Free Workshop
Introducing the New Affordable and Durable Q Exactive Mass Spectrometer for Routine Applications
Martin Hornshaw, Application Support Manager

Poster Viewing Session

Diagnosis of Disorders Affecting Steroid Synthesis and Metabolism by Mass Spectrometry
Josep Marcos del Aguila, Researcher, Institut Hospital del Mar d'Investigacions Mèdiques, Spain

The use of mass spectrometry for the study of the altered excretion of steroidal metabolites in several pathologies, the development of diagnostic methods and their application in the clinical practice will be discussed.

Coffee and Networking in Exhibition Hall

Contributions of Mass Spectrometry in the Diagnosis and Management of Hypothalamic–pituitary–adrenal Axis Disorders
Gregori Casals, Scientist, Hospital Clínic Barcelona, Spain

Main contributions and possibilities of mass spectrometry in the clinical diagnosis and management of hypothalamic–pituitary–adrenal axis disorders will be discussed.

Close of Conference