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Automated Continuous-Flow Synthesis of ADCs and Oligonucleotide Monomers

Sunday, 7 June 2026 at 14:00

Add to Calendar ▼2026-06-07 14:00:002026-06-07 15:00:00Europe/LondonAutomated Continuous-Flow Synthesis of ADCs and Oligonucleotide MonomersFlow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com

Automated synthetic systems for both antibody–drug conjugates (ADCs) and oligonucleotide monomers were developed, enabling two-step fully continuous-flow synthesis in both cases. The reaction time has been dramatically reduced from 8–12 hours to less than 20 minutes. For ADC synthesis, the reaction temperature has been raised from low temperature to room temperature. For oligonucleotide monomer synthesis, no additional catalyst or base is required. These advances represent breakthroughs in terms of space efficiency, time savings, and environmental friendliness.

Fang Zhao, Professor School of Pharmacy, East China Normal University

Fang Zhao is a Professor at the School of Pharmacy, East China Normal University (ECNU), and Director of the ECNU Joint Laboratory for AI-Enabled Drug Manufacturing. Her research focuses on microreactor technology and intelligent drug manufacturing. As a principal investigator, she has led 10 projects, including those funded by the National Natural Science Foundation of China (NSFC), and the Shanghai Major Science and Technology Project. She has published over 20 SCI papers as first or corresponding author and holds 4 authorized patents.