Tuesday, 7 February 201708:45 | Welcome Address from the Flow Chemistry Society
Ferenc Darvas, Chairman, Flow Chemistry Society, Switzerland
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Session 1: Back to Einstein - Electrification of Chemistry - Making use of the Smallest Units, Photons and Electrons | | Session Chair: Mimi Hii, Professor, Imperial College London, United Kingdom |
| | 09:00 |  | Conference Chair Electrification of Chemistry
Volker Hessel, Professor, Eindhoven University of Technology, Australia
New smart electromagnetic activation modes (photo, ultrasound, plasma, microwave, etc. with their discrete rotational, vibrational, electron levels) provide a powerful alternative to temperature activation (Maxwell-Boltzmann theory: collision, momentum, probability). This process innovation needs a window of opportunity such as the ‘Plasma Agriculture’ which opens the door to ‘Fertilizing with the Wind’ in ‘Plants on Wheels’. |
| 09:45 | Bringing Diazomethane to the Bench: A Lab-Scale Reactor for the Continuous Generation of Anhydrous Diazomethane
Doris Dallinger, Postdoctoral Research Associate, University of Graz, Austria
In this presentation the in-situ on-demand generation of anhydrous diazomethane using membrane technology in a tube-in-tube or tube-in-flask reactor will be covered. These concepts allow safe and convenient preparation and handling of diazomethane. | 10:15 | Extended Path Flow Electrosynthesis Reactors as a Simple and Scalable Tool for Organic Synthesis
Richard Brown, Professor, University of Southampton, United Kingdom
Extended path length microfluidic electrochemical reactors and how they facilitate the synthesis of multiple grams per hour of interesting products will be discussed and exemplified with a variety of stimulating synthetic examples. | 10:45 | Coffee & Networking in Exhibition Hall | |
Session 2 | | Session Chair: Thomas Wirth, Professor, Cardiff University, United Kingdom |
| | 11:15 | Photopolymerizations in Continuous Flow: From Highly Efficient to Overefficient Reactions
Thomas Junkers, Professor, Hasselt University, Belgium
Photoflow reactions for the development of prescision macromolecular materials are discussed. The high efficiency of photocontrolled polymerizations is highlighted, but also over-efficiencies with respect of the use of conventional photoinitiators in flow reactions are demonstrated. | 11:45 |  | Keynote Presentation A Conceptually New Photomicroreactor Design for Energy-efficient Solar Photochemistry
Timothy Noël, Professor, University of Amsterdam, Netherlands
We will present our results concerning a novel device integrating the luminescent solar concentrator (LSC) concept with photomicroreactors, allowing the direct use of solar light in photochemistry without the need for any intermediate energy conversion. This leaf-inspired photomicroreactor based on fluorescent dye-embedded polydimethylsiloxane collects sunlight, focuses the energy to a narrow wavelength region, and then transports that energy to embedded microchannels where the flowing reactants are converted. |
| 12:30 |  Technology Spotlight:
Autonomous Phase Separator - An Integrated Part of Internet of Lab (IoL) Application
Julian Heinrich , Chemist , Little Things Factory
Separating two phases with dynamic respective flowrates can not be done with static separators. Actively controlled phase separators use the power and flexibility of modern microcontrollers in embedded systems. A smart microcontroller software allows a self-regulating phase separator, which even handles the absence of one phase without tangling.
| 12:45 | Lunch & Networking in the Exhibition Hall | 13:15 |  Poster Viewing Session
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Afternoon Session Sponsor | Session Sponsors |
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Session 3 | | Session Chair: Dominique Roberge, Group Leader, Lonza Group Ltd, Switzerland |
| | 13:45 | Anelli's (TEMPO) Oxidation of Alcohol by Flow Chemistry, Industrial Scale
Guy Samburski, Senior Director R&D, TEVA , Israel
A batch process for TEMPO oxidation was successfully converted to a flow process in industrial scale, for an Active Pharmaceutical intermediate. Yield was significantly increased and low temperatures could be avoided. | 14:15 | Aerobic Oxidation of Aldehydes: Lessons Learned and to be Learned using Continuous Flow Microreactor
Alain Favre-Reguillon, Associate Professor, University of Lyon, France
This talk will highlight the advantages of continuous flow gas-liquid processes for aerobic oxidation of aldehydes. The benefits given by continuous flow technology, including safety, renders the procedure synthetically very interesting and results in the development of improved protocols. | 14:45 | 'Complexity Generation by Photochemistry In Flow : From Grams to Kilograms’
Kevin Booker-Milburn, Professor, University of Bristol, United Kingdom
This lecture will describe the development of a number of photochemical reactions for the formation of complex organic molecules with applications in drug discovery and natural product synthesis. In particular the use of novel flow reactors for the photochemical synthesis of multigram quantities will be described. The lecture will also introduce ’The Firefly’ ; a novel, small-footprint reactor that enables the synthesis of multi-kilogram amounts of photoproduct per-day within a standard 1.5 meter fumehood.
| 15:15 | Electro-organic Synthesis: Metal- and Reagent-free
Siegfried Waldvogel, Professor, Johannes Gutenberg-University Mainz, Germany
Within this presentation the potential of electroorganic synthesis for value-added products – precursors for ligands or pharmaceutically intermediates - will be outlined. The examples cover the whole ranging from efficient screening to scale-up of the electrosynthetic process. | 15:45 | Coffee & Networking in Exhibition Hall | |
Session 4: Back to Health – Medicinal Flow Chemistry in the Era of FDA’s Door Opening Towards Emerging Technologies | | Session Chair: Claudio Battilocchio , Dr , University of Cambridge , United Kingdom |
| | 16:15 | Taming Diazo Transfer Chemistry in Flow
Anita Maguire, Professor of Pharmaceutical Chemistry, University College Cork, Ireland
Enabling the safe application of diazo chemistry in process chemistry through use in flow ; enhanced control of the synthesis leading to enhanced yields, purity and ease of scale-up | 16:45 | Application of Flow Chemistry Techniques to the Drug Discovery Process
Stevan Djuric, Senior Director, Discovery Chemistry and Technology, AbbVie, United States of America
The talk will focus on application of several flow chemical techniques including photochemistry, electrochemistry and high temperature chemistry to provide additional opportunities to the medicinal chemistry engaged in drug discovery activities. | 17:15 | Fast Mixing, Ketimine Additions, and the Application of Flow Chemistry to Verubecestat
John Naber, Director, Flow Chemistry and Lab Automation, Process Research & Development, Merck & Co, United States of America
The development of a novel method for ketimine additions enabled a key step in the synthesis of Merck Sharpe and Dohme’s (MSD) Phase III compound for Alzheimer’s disease. The production of hundreds of kilograms of material in a pilot plant campaign and the associated mixing studies at lab and plant scale are presented. | 17:45 | Flow Chemistry from Industrial R&D to Industrial Applications
Stéphane Laurent , Head of Department, Innovative Technologies, Servier, France
Two industrial applications will be presented, one with several unit operations (several tons/year) and a second in the environmental field. | 18:15 | Flow Reactor Technologies and Scale-up Methodology
Dominique Roberge, Group Leader, Lonza Group Ltd, Switzerland
This work is focused on characterizing and developing models for the overall mass transfer performance of micro/milli reactors. It will be shown that the hydraulic diameter of different mixers can be adjusted for flow rates via the 3/7 power rule. | 18:45 | End of Day 1 | 20:00 | Conference Gala Dinner |
Wednesday, 8 February 2017 |
Session 5 | | Session Chair: Volker Hessel, Professor, Eindhoven University of Technology, Australia |
| | 08:30 | Whole-cell Biotransformations within the Microflow Systems
Polona Žnidaršic Plazl, Professor, University of Ljubljana, Slovenia
Whole-cell biocatalysis and microreactor technology are gaining importance in modern biotechnology. This lecture will highlight a few examples using yeast and bacterial cells for establishing continuous biocatalytic processes in a microflow systems. | 09:00 | Microscale Technology and Biocatalytic Processes: How to Minimize the Gap Between Research and Industry
Igor Plazl, Professor, University of Ljubljana, Slovenia
This lecture will discuss the microscale bioprocess development based on scale-up/ numbering-up concept. The design of packed bed microreactor “between two-plates“ will be presented together with innovative approaches, protocols, and tools to minimize the gap between research and industry.
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Back to Nature - End-to-end Continuous-flow Production | | Session Chair: Mimi Hii, Professor, Imperial College London, United Kingdom |
| | 10:00 | Around the World Synthesis: Harnessing the Cloud for Organic Chemistry
Daniel Fitzpatrick , Researcher, Ley Group, University of Cambridge, United Kingdom
During this talk, the use of cloud-computing will be explored in the context of practical organic synthesis. Showcase examples will be discussed and the problem-solving approach used for flow API synthesis will be highlighted. | 10:30 | Coffee & Networking in Exhibition Hall | |
Session 6 | | Session Chair: Richard Brown, Professor, University of Southampton, United Kingdom |
| | 11:00 | Self-optimising Flow Reactors
Richard Bourne, Lecturer in Reaction Engineering, University of Leeds, United Kingdom
This talk will discuss the development of automated reactor platforms for the rapid optimisation of complex reaction systems and give industrially relevant case studies and integration of advanced analytical techniques. | 11:30 | Continuous Efficient Multistage Extraction
Andrea Adamo, Chief Executive Officer, Zaiput Flow Technologies, United States of America
We present an approach to flexible and scalable flow based multistage liquid-liquid extraction. We provide background, discuss system design and implementation, show benchmarking of our set up with respect to literature test systems, show a complex multicomponent example and discuss scalability. | 12:00 |  Technology Spotlight:
SpinPro Reactor Technology for Flow Chemistry
Wouter Stam, Managing Director, Flowid Products BV
This talk will be about the use of SpinPro reactors and their applications, especially multiphase and precipitation reactions.
| 12:15 | Lunch & Networking in the Exhibition Hall | 13:00 | Poster Viewing Session
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Session 7 | | Session Chair: Kevin Booker-Milburn, Professor, University of Bristol, United Kingdom |
| | 13:30 | Integrated Synthetic Platforms for Chemical Probes: A Journey through the Routes of Flow Processing
Antimo Gioiello, Associate Professor, University of Perugia , Italy
The talk will focus on our recent efforts directed towards the design and implementation of integrated flow platforms for the production of chemical probes and compound library in drug discovery programmes. | 14:00 | Enz-Flow: Continuous Bioprocessing for Greener API Synthesis
Amanda Evans, Assistant Professor, California State University Fullerton, United States of America
“The Evans group is applying the unified use of continuous processing and continuous bioprocessing/engineered enzyme catalysis (“Enz-Flow”) towards novel syntheses of three key active pharmaceutical ingredients.”
| 14:30 | Coffee & Networking in Exhibition Hall | |
Session 8 | | Session Chair: Stevan Djuric, Senior Director, Discovery Chemistry and Technology, AbbVie, United States of America |
| | 14:45 | Step-by-step Towards End-to-end: Examples of Integrated Processes for the Continuous Production of Pharmaceuticals
Heidrun Gruber-Wölfler, Associate Professor, Graz University of Technology, Austria
Different examples of continuous pharmaceutical manufacturing will be presented. The focus of this presentation will be on the coupling of synthesis and crystallization in flow with a follow-up in continuous secondary manufacturing. | 15:15 | Flow Electrochemistry
Thomas Wirth, Professor, Cardiff University, United Kingdom
The development of a flow microreactor for electrochemistry will be discussed alongside first applications in synthesis. | 15:45 | Bridging Industry and Academia with Enabling Technologies
Claudio Battilocchio , Dr , University of Cambridge , United Kingdom
This talk will show specific examples of industrial challenges that were solved using specific enabling solutions. | 16:15 | Best Poster Award Announcement
| 16:20 | Cose of Conference Address
Ferenc Darvas, Chairman, Flow Chemistry Society, Switzerland
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