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SELECTBIO Conferences Flow Chemistry Asia 2022

Flow Chemistry Asia 2022 Agenda



Co-Located Conference Agendas

Flow Chemistry Asia 2022 | 3D-Bioprinting, Biofabrication, Organoids & Organs-on-Chips Asia 2022 | Lab-on-a-Chip and Microfluidics Asia 2022 | 

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Thursday, 6 October 2022

08:00

Conference Registration, Materials Pick-Up, Morning Coffee and Tea


Session Title: Conference Opening Session -- Flow Chemistry Asia 2022

09:00

Paul WattsConference Chair

Continuous Flow Drug Manufacturing in Africa
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

While Africa has a variety of companies that formulate medicines it has very little active pharmaceutical ingredient (API) manufacturing, with the consequence that these need to be imported. This results in increased drug costs, making medications unaffordable to most patients in Africa.  Economic, social and political stresses have been witnessed all over the world during the COVID-19 pandemic. In particular, drug shortages and inaccessibility is one of the many results of disruption of supply chains due to the shutdown of manufacturing activity, as well as export restrictions and bans by other countries. To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. A selection of examples will be presented.

09:30

Thomas WirthKeynote Presentation

Intensification and Electrification of Flow Chemistry
Thomas Wirth, Professor, Cardiff University, United Kingdom

The advantages of increased mixing of biphasic reaction mixtures in flow offers great potential compared to conventional flask techniques, especially when combined with microwave irradiation or phase transfer catalysis. The presentation will also illustrate that metal-catalyzed reactions and enzyme-promoted transformations can be performed advantageously in biphasic systems. The development of a microreactor for electrochemistry including several applications will be discussed.

10:00

Stoli ChemCSTR Series: Where Usual Chemistry Does Not Flow
Nikolay Cherkasov, Managing Director, Stoli Chem

Conventional flow reactors such as tubes and chips are excellent. Their scaling up, however, is difficult because fluid velocity determines residence time, pressure drop, and mixing/heat transfer. CSTRs, on the other hand, provide mixing independent of flow rates and could handle exothermic, multiphase, and reactions with solids. We discuss case studies where such capabilities improve process throughput and yield.

10:30

Mid-Morning Coffee, Tea and Networking in the Exhibit Hall

11:00

SyrrisHow Flow Chemistry Can Impact the Early Drug Discovery Process?
Andrew Mansfield, Flow Chemistry Leader, Syrris

Flow chemistry is a growing technology in the pharma industry, where it has proved itself invaluable, especially in the process development phase of drug discovery. However, the hit-to-lead and lead-generation phases have been slower to embrace these techniques. The potential benefits are huge, particularly for rapid library generation and challenging chemistries that were previously hard to achieve by traditional batch methods. The content of this presentation looks at how researchers in early drug discovery, who are looking for practical and efficient ways to increase their productivity and shorten the hit-to-lead times can achieve this through the use of flow chemistry techniques.

11:30

Fuji-TechnoTriplex Plunger-driven Diaphragm Pumps
Taro Yanagiuchi, Sales Manager, Fuji-Techno

We will be presenting two new offers to our portfolio. 1st our newly developed diaphragm pump, which unlike others, can handle a vast majority of slurry liquids. 2nd our AI software which further minimizes pulsation thru AI learning of the pulsation patterns and adjusting the motor speed. In the introduction, we will explain the operating principles, performance, benefits of our innovative products.

12:00

Networking Lunch in the Exhibit Hall -- Visit Exhibitors and View Posters -- Japanese Bento Box Lunch


Session Title: Flow Chemistry Asia 2022 -- Emerging Trends in Flow Chemistry Session

14:00

Micro-Flow Synthesis of Specialty Peptides
Shinichiro Fuse, Professor, Nagoya University, Japan

Amide bond formation via generation of highly electrophilic species was developed. Undesired reactions were successfully suppressed by using micro-flow technologies.  The developed approach was used for synthesis of specialty peptides.

14:30

Automation-assisted Kinetic Study and Reaction Optimization in Flow
Shusaku Asano, Assistant Professor, Kyushu University, Japan

Integrated operation of pumps, valves, and sensors enabled systematic investigation of the reaction kinetics. Extreme conditions such as 1 s reaction at 120? with hexane solvent were easily conducted in a flow system. An optimum modifier for a selective catalytic reaction was also examined with a catalyst-coated reactor.

15:00

Flow Chemistry and Reaction Engineering - Application to the Synthesis of Neuroprotective Agents
Darren Riley , Associate Professor, University of Pretoria , South Africa

The presentation will focus on the development of end-to-end flow-based synthetic routes to pharmaceuticals with a neurological focus and will include aspects of batch-flow hybridization and reaction engineering. Insight will also be given pertaining to the use of flow technology as a disruptive leap-frogging technology for the localization of pharmaceutical manufacturing in developing countries.

15:30

Mid-Afternoon Coffee and Tea Break and Networking in the Exhibit Hall

16:00

Flow-based Process Development to Support the Localization of Active Pharmaceutical Ingredient Manufacturing in Africa
Jenny-Lee Panayides, Principal Scientist and Research Group Leader, CSIR Biosciences South Africa, South Africa

The presentation will focus on the efforts to adopt flow technology in developing countries for the manufacture of active pharmaceutical ingredients. Case studies will highlight the development of a flow-based route to a non-steroidal anti-inflammatory drug and discuss recent efforts to develop an economical platform for controlling and automating flow equipment.

16:30

Shu KobayashiKeynote Presentation

Title to be Confirmed.
Shu Kobayashi, Professor, The University of Tokyo, Japan

17:00

Close of Programming on Day 1 of the Conference

Friday, 7 October 2022

08:00

Morning Coffee, Tea and Networking in the Exhibit Hall

09:00

Dong Pyo KimKeynote Presentation

Novel Microfluidic Platforms for Scale-Up Production and Autonomous Self-Optimization
Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH), Korea South

Flow chemistry in the confined microfluidic space enables easy up-scaling production at precise controlled conditions. In the talk, we show the assembly of 16 numbering-up 3D printed metal microreactor to render high productivity up to 20 g for 10 min operation of subsecond ultrafast chemistry. And, hexagon-shaped 3D printed polymer module of photomicroreactor with solar concentrator leaded to facile assembly into serial and radial reconfiguration for high throughput of synthesis. In addition, for scalable production of emulsions, compact 3D printed droplet generator was devised by array of 40 drop-makers with a 3D void geometry and a flow distributor, producing microgels and microparticles. Finally, we explore ultrafast flow chemistry by autonomous self-optimizing platform that accelerates the optimization and screening of complex chemistry.

09:30

Microfluidics and Flow Chemistry In Radiochemistry: A Perfect (Future) Match?
Giancarlo Pascali, Professor, University of New South Wales, Australia

The use of microfluidic systems and flow chemistry was pioneered in radiochemistry in 2004; since then, numerous researchers have shown how using these techniques can provide a much better yield, economy, reliability and safety. This talk will give several examples demonstrating how the unique features of these approaches are a perfect match with the numerous challenges of radiochemistry. However, currently only a small number of commercial synthetic systems adopt these concepts; the last part of this talk will be aimed at proposing some causes for this surprising fact, potentially stimulating useful synergies with the traditional pharmaceutical manufacturing actors.

10:00

Tanja JunkersKeynote Presentation

It's a Machines World: Challenges and Opportunities in Automated Polymer Synthesis
Tanja Junkers, Professor, School of Chemistry, Polymer Reaction Design group, Monash University, Australia

Contemporary macromolecular chemistry has matured to a point where virtually any polymer structure can be synthesized via combinations of controlled polymerization approaches, post-polymerization modification and efficient ligation strategies. Still, often large hurdles have to be overcome to take the next step in research, that is being able to provide such complex materials reliably on significant scale for use in advanced applications. A solution to this problem is to make use of continuous flow synthesis techniques. Flow reactors are associated with high reproducibility, intrinsically simple reaction scale-up and improved product qualities due to significant reduction of side reactions. Being an established method especially in the pharmaceutical chemistry domain, full potential with regards to macromolecular synthesis did not unfold until very recently. Among others, the benefits of using online-monitoring, reactor automation and machine-learning will be discussed and the development of fully autonomous based reactor systems presented. Also polymer self-assembly itself can largely benefit from flow operation, and first advances in this area will be presented. The potential of flow chemistry for preparative macromolecular chemistry will be discussed and explored on the example of polymerization. Further, the possibility to build reactor cascades and the advantages of online-monitoring will be highlighted. Machine-assisted synthesis of polymers is shown to be superior in accuracy in synthesis. Generally, the introduction of smart algorithms in synthesis control opens avenues into the digital chemistry space, and challenges and opportunities in this realm will be discussed.

10:30

Mid-Afternoon Coffee and Tea Break and Networking in the Exhibit Hall

11:00

Volker HesselKeynote Presentation

Flow Synthesis of Phosphorus Nanocomposites for Controlled Fertilizer Release and Wheat Growth
Volker Hessel, Professor, School of Chemical Engineering, The University of Adelaide, Australia

Flow chemistry has shown distinct advantages in the synthesis of nanomaterials. Here, we investigate flow chemistry for the synthesis of nanofertilizers which has been so far less reported in literature. New generations of P fertilizer have been developed in batch synthesis. In 2020, Hessel et al. proposed a process for leaching phosphorus from mimicked moon crust using a re-entrance flow microfluidic device and using this to fertilize lettuce in “space greenhouses”, and recycling phosphate from lettuce root via burning in a furnace.
 
In this research, a coiled inverted flow system, was used to prepare a slow released P-containing fertilizer and this system also allowed the direct adsorption of low molecular weight organic acid anions (LMWOAs). Citrate ions, as the chosen LMWOAs, were incorporated with the above prepared phosphorus fertiliser to form a compound fertilizer capable of releasing nutrients in a slow manner and reducing the P binding sites in P deficient soil. The nutrient performance was investigated in a model soil mixture. The system allowed the one-stage production of LMWOAs adsorbed apatite with the maximum adsorption capacity of 0.19 gcitrate.gaptite-1 in a continuous manner. The presence of citrate ions in the prepared material increased the P availability in the model soil mixture by 2.6 times compared to commercial apatite. After 14 days of application, about 57% of P in the prepared fertilizer was released into the soil solution.  

We will also report about an extension of the approach here towards nanoencapsulation by chitosan and using more innovative continuous-flow reactor equipment, including the Corning and StoliFlow reactors. We will compare the wheat growth efficiency of the flow-made phosphorus nanofertilizers with plasma-made nitrogen (carbon dot and solution-based) fertilizers, which we also prepare.

11:30

Emulsion Polymerization In Ultrasonic Microreactors
Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven, Belgium

Polymeric dispersions have broad applications in adhesives, coatings, catalyst support, encapsulation, and drug delivery. One approach is the generation of miniemulsions (50nm<d<1000nm) and subsequent polymerization to synthesize polymer nanoparticles that can achieve the desired size and morphology for targeting a specific application. Ultrasonic microreactors have proven to be effective in the generation of miniemulsions, although with a high polydispersity (PDI > 0.3). To address this issue, an ultrasonic microreactor was developed, which enables the generation of a monodisperse miniemulsion (PDI < 0.3) to synthesize polymer nanoparticles. This ultrasonic microreactor consists of serpentine channels with a square cross-section of 1.2 mm in borosilicate glass with a piezoelectric plate transducer attached to one side. The miniemulsion created by the cavitation activity in the ultrasonic microreactor is then fed into a temperature controlled (75°C) coiled loop reactor for the continuous polymerization of monomer droplets. Specifically, we study the cross-linking polymerization of butyl methacrylate, for which the continuous phase is water with a surfactant (Lutensol AT50), and the dispersed phase consists of the monomer butyl methacrylate, the cross-linking agent ethyl glycol dimethacrylate, the costabilizer hexadecane and the thermal initiator AIBN. Preliminary results highlight the performance of the developed system. For a dispersed to continuous volumetric flow rate ratio of 1:4, residence time of 4 min at a US frequency and power of 47kHz and 15W, particles with a mean hydrodynamic diameter of 94 nm and PDI of 0.15 were obtained. The influence of the operating parameters (load power, frequency, surfactant concentration, flow rate ratio and residence time) on the size of the miniemulsion droplets and to control the final particle size will be discussed in detail.

12:00

Networking Lunch in the Exhibit Hall -- Visit Exhibitors and View Posters -- Japanese Bento Box Lunch


Add to Calendar ▼2022-10-06 00:00:002022-10-07 00:00:00Europe/LondonFlow Chemistry Asia 2022Flow Chemistry Asia 2022 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com