Thursday, 26 May 2016 | Agenda |
| | 08:00 | Registration | | Session I: Current Trends in Disease Diagnosis 1 |
| | 09:00 | | Keynote Presentation Latest Technologies for Disease Identification and Diagnosis Lakshmi V Ramanathan, Chief, Clinical Chemistry Service, Memorial Sloan Kettering Cancer Center, United States of America
This Keynote Presentation will bring latest insights into the innovative technologies in disease identification. It will discuss the roadmap from Laboratory bench to bedside in the context of evidence based laboratory medicine. Further, it will discuss the impact & role of advances in technology and informatics in the standardization of methodologies (eg tumor marker standardization). Also, it will then mention studies involving interfering substances, limitations and reference ranges along with data interpretation which finally helps in the effective treatment of the patient. |
| 10:00 | Formalin Fixed and Paraffin Embedded Tissue Based Assays for Disease Diagnosis Narayanappa Rajeswari, Associate Professor, Dayananda Sagar College of Engineering, India
In this talk, recent progress in extraction and diagnostic techniques using FFPE tissue will be discussed. It will also cover novel technologies for rapid and simultaneous analysis of many FFPE patient samples which is crucial for treatment decisions. Finally, it will mention about how data from FFPE tissue based assays complements disease diagnosis and also allows designing of personalized therapeutic regimens. | 10:45 | Coffee Break and Networking Session | | Session II: Current Trends in Disease Diagnosis 2 |
| | 11:15 | The Development of Salivary Biomarkers to Detect Systemic Diseases Chamindie Punyadeera, Associate Professor, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
In this presentation, the speaker will discuss the technology developed for quantifying CRP levels in saliva samples and its use as a biological matrix to detect ischemic heart disease and heart failure. The talk will also mention how by analysis of salivary DNA methylation and miRNA signatures along with identification of tumour suppressor genes, cancers like head and neck cancer, especially oral cavity cancers can be detected. Further, it will discuss about role of (MSP) assay and panel of nine miRNA markers in determining specific methylation events. Finally, it will highlight how saliva is an ideal biological medium to detect both oral and systemic events along with future prospects. | 12:00 | Comparative Reproducibility of SYBR Green I and TaqMan Real-time PCR Chemistries for the Analysis of Matrix and Hemagglutinin Genes of Influenza A Viruses Madhu Khanna, Associate Professor, Delhi University, India
This presentation will discuss about Real-time quantitative PCR (qPCR) as a leading edge technology for evaluation of the expression of nucleic acids and how it has become a foremost need in diagnosis and research works. Specificaaly, it will discuss the present study of evaluaton of the sensitivity and specificity of two chemistries of real-time RT-PCR (with the use of fluorescent SYBR Green I dye and specific TaqMan probe) for detection of the matrix and hemagglutinin genes of human influenza A viruses. | 12:45 | Lunch Break and Networking Session | | Session III: Cancer Diagnostics |
| | 13:45 | Development and Validation of NGS-based Clinical Cancer Panels for Precision medicine in Asian and Causasian Adult Cancers Winston Patrick Kuo, President, Predicine Holdings Ltd, United States of America
This presentation will discuss about PanCancer NGS Panel designed by leaders in the field that comprises of all exon coding and selected hotspots of critical cancer genes in the most common cancer types for both Asian and Caucasian cohorts. It will further mention the role of this panel for detection of known and novel variants & to advance research into personalized cancer treatment and for use in clinical trials to help the development of new targeted therapies. | 14:30 | Development and Validation of Novel Diagnostic Test For Prediction of Risk of Recurrence for Breast Cancer Patients:Beyond ER, PR & Her-2/neu Manjiri Bakre, Founder and CEO, OncoStem Diagnostics Pvt Ltd., India
This talk will focus on development and validation of OncoStem:Breast test for ER+/PR+/Her2- or +/Lymph node – or + IDC of breast patients. | 15:15 | Coffee Break and Networking Session | | Session IV: Advances in Diagnostic Approaches |
| | 15:30 | ‘TissueQuant’ – A Colour Intensity Quantification Tool – For Medical Research and Diagnostics Keerthana I Prasad, Associate Professor, Manipal University, India
This talk would provide explanation of how this technique of quantification could be useful in quantification of a particular substance of interest in a given biological specimen. Use of such a quantification in a couple of applications each for both medical research and diagnosis and the results of these research projects would be presented. The talk would conclude with pointers to the different possibilities of use of TissueQuant for a host of other applications. | 16:15 | NGS in the Clinical Lab – Analysis and Interpretation of Data Honey Reddi, Clinical Laboratory Director, The Jackson Laboratory, United States of America
This talk will present an overview of the steps involved in NGS test development, analysis of the vast amount of data generated and the tools used for variant annotation and interpretation. Also presented will be the American College of Medical Genetics and Genomics professional standards and guidelines developed to assist clinical laboratories with the validation of next-generation sequencing methods and platforms, the ongoing monitoring of next-generation sequencing testing to ensure quality results, and the interpretation and reporting of variants found using these technologies. | 17:00 | Integrative Translational Big-Data Analysis to Identify Predictive Biomarkers and Drug-Target Interactions Rajani Kanth Vangala, Director of Research, Thrombosis Research Institute, India
In this talk, development of a novel approach of integrating clinical data of more than 11,000 subjects’ data suffering from Heart disease and stroke with genomics and proteomics research outcomes will be discussed. Along, it will deliberate about biomarkers identification for improved risk prediction and diagnosis. Furthermore, it will highlight how using network analysis, drug-target interactions can be developed for improved drug development. Finally, it will mention that how these approaches are now also applied in other diseases for novel biomarkers and drug targets. | 17:45 | End of First Day of Conference |
Friday, 27 May 2016 | Session V: Novel Diagnostic Techniques 1 |
| | 09:00 | Diagnosis of Brain TB: How Small Steps Leads to Big Changes Rajpal Singh Kashyap, Senior Scientist (Medical) and Head, Central India Institute of Medical Sciences, India
In this talk, proteomic techniques, one & two dimensional electrophoresis, immunological and molecular tools for identification of markers specific to brain TB (Tuberculous meningitis) will be discussed. Further, it will also discuss use of these biomarkers to develop diagnostic kit for the prediction and/or early diagnosis of Brain TB and also to understand the pathogenesis of disease. | 09:45 | | Keynote Presentation Novel Analytical Techniques for the Characterization of Bacterial and Viral Infections Mark Broenstrup, Professor & Head, Chemical Biology, Helmholtz Centre for Infection Research, Germany
In this Keynote talk, improved methods for accurately diagnosing the infectious pathogens in the presence of beneficial colonizing microbes and characterization of its phenotype will be discussed. Specifically, the speaker will discuss their work on two diagnostic methods. Firstly, application of electrochemical impedance spectroscopy for characterizing P. aeruginosa biofilms will be highlighted followed by presentation on use of peptide arrays printed on glass slides to characterize viral infections (‘chip serology’). |
| 10:45 | Coffee Break and Networking Session | | Session VI: Novel Diagnostic Techniques 2 |
| | 11:15 | | Keynote Presentation Nuclear Acid based Diagnostic with Paper Microfluidics Patrick Tabeling, Professor, ESPCI Paris Tech, France
This talk will focus on the diagnosis of contagious diseases like Ebola, HIV and dengue by Ribonucleic Acid (RNA) isothermal reverse-transcription (RT) and Recombinase Polymerase Amplification (RPA) of synthetic RNA strands. Further, it will also discuss about multiplex system that enables simultaneous detection of several RNA strands on a paper device. |
| 12:15 | Onsite Multiplex Device for Early Prediction of Kidney Damage Kadamb Patel , Program Manager & Research Scientist, Temasek Polytechnic, Singapore
In this talk, development of simple, point of care paper based multiplex device for early prediction of kidney damage will be discussed. It will further highlight biomarkers with high sensitivity and specificity, which can be used for early prediction of AKI Kidney injury molecule-1 (KIM-1) and Neutrophil gelatinase-associated lipocalin (NGAL). Finally, it will mention the advantages of the multiplex device. | 13:00 | MicroRNA-99 determines the Fate of Cardiac Hypertrophy and Heart Failure Ramasamy Subbiah, Assistant Professor, Madurai Kamaraj University, India
This talk will discuss how Upregulated MicroRNA-99 expression during pathological hypertrophy suggests that it can be a valuable diagnostic marker for heart failure. | 13:30 | Lunch Break and Networking Session | | Session VII: Enabling Technologies in Medicine |
| | 14:30 | Coverage and Reimbursement of Personalized Drugs Franz Hessel, Professor, SRH University , Germany
This talk describes the challenges of the evaluation of personalized drugs for reimbursement decisions on pharmaceuticals and accompanying biomarker tests in selected countries such as US, UK and Germany and the challenges for drug as well as test manufacturers to successfully access the market of reimbursed technologies. | 15:15 | Simultaneous Determination of Steroid and Vitamin D by LCMS/MS Shailesh Damale, Assistant Manager, Shimadzu Analytical (India) Pvt Ltd, India
This talk will discuss about determination of Steroid and Vitamin D using LCMS/MS technique. Further, it will also highlight the limitations of immunoassays and will focus on the techniques which improve throughput including direct sample injection, LC-multiplexing and sample multiplexing. Finally, it will discuss the investigations of new applications of LCMS/MS in metabolomics and metallomics. | 15:45 | | 16:45 | Coffee Break and Networking Session | | Plenary Talk |
| | 17:00 | | Keynote Presentation Precision Medicine: The Future of Data Driven Healthcare Claudio Carini, MD, PhD, FRCPath, Global Head, Clinical Immunology & Biomarkers, Pfizer Inc, United States of America
In this Keynote Talk, the role of biomarkers and companion diagnostics (CDX) in enabling shift from empirical medicine to precision medicine (PM) will be discussed. It will mention how PM is expected to provide a rapid acceleration in the development of next-generation pharmacotherapy. In conclusion, the talk will highlight that any treatment decision should rely on a deep understanding of both the disease biology and the mechanism of action of a given drug. Finally, it will discuss how advances in molecular diagnostics has led to the development and inclusion of CDX assays, in a few disease areas, which can provide insight to more rational therapeutic approaches. This ultimately will change how medicine will be practiced and taught in future. |
| 18:00 | End of Conference |
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